Pharmacological management of cognitive deficit in schizophrenia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F13%3A43914450" target="_blank" >RIV/00023752:_____/13:43914450 - isvavai.cz</a>
Result on the web
<a href="https://www.novapublishers.com/catalog/product_info.php?products_id=10607" target="_blank" >https://www.novapublishers.com/catalog/product_info.php?products_id=10607</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Pharmacological management of cognitive deficit in schizophrenia
Original language description
Cognitive deficit represents the core impairment in schizophrenia that fundamentally affects course and functional outcome of illness. Thus far, generally held views claim that conventional antipsychotics are less effective in cognitive remediation; furthermore, cognition may be worsened by the adjuvant anticholinergic medication used to alleviate from side effects. However, several earlier and recent reports indicated that a low dosage of typical antipsychotics may possess procognitive properties. Unequivocally positive effects of virtually all second-generation antipsychotics in remediation of a cognitive deficit have been shown in both individual studies and meta-analyses. The key role in cognition is played by dopamine activity in the prefrontal cortex. Dopamine action is mediated through D1 receptors, as evidenced by the improvement of cognitive performance following administration of D1 agonists. Stimulation of dopamine neurotransmission is rate-limited: low doses enhance cogniti
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
FL - Psychiatry, sexology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/1M0517" target="_blank" >1M0517: Center of Neuropsychiatric Studies 2005-2009 (Neurobiology in Clinical Application)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Cognitive Deficit in Mental and Neurological Disorders
ISBN
978-1-60741-957-0
Number of pages of the result
13
Pages from-to
139-151
Number of pages of the book
454
Publisher name
Nova Science Publishers
Place of publication
New York
UT code for WoS chapter
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