Relationship of ketamine's antidepressant and psychotomimetic effects in unipolar depression

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F13%3A43914593" target="_blank" >RIV/00023752:_____/13:43914593 - isvavai.cz</a>

Result on the web

<a href="http://www.rediviva.sav.sk/55i1/57.pdf" target="_blank" >http://www.rediviva.sav.sk/55i1/57.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Relationship of ketamine's antidepressant and psychotomimetic effects in unipolar depression

Original language description

OBJECTIVES: Ketamine and other NMDA (N-methyl-D-aspartate) antagonists produce fast-acting antidepressant-like effects, although the underlying mechanism is unclear. Furthermore, high affinity NMDA antagonists such as ketamine are associated with psychotomimetic effects. To date the link between the antidepressant and psychotomimetic effects of ketamine has not been explored. We examined the relationship between the antidepressant and psychotomimetic effects of a single ketamine infusion in subjects diagnosed with major depressive disorder. METHODS: In a double-blind, cross-over, placebo-controlled, two weeks clinical trial we studied the effects of ketamine (0.54 mg/kg within 30 min) in a group of 27 hospitalized depressive patients. RESULTS: Higher intensity of psychotomimetic symptoms, measured using BPRS, during ketamine administration correlated with alleviation in mood ratings during the following week with maximum on day seven. Ketamine was superior to placebo in all visits (day 1, 4, and 7) assessed by MADRS with effect size (Cohen's d) of 0.62, 0.57, and 0.44 respectively. There was no significant correlation between ketamine and nor-ketamine plasma levels and MADRS score change at any study time point. CONCLUSION: The substantial relationship between ketamine's antidepressant and psychotomimetic effects was found. This relationship could be mediated by the initial steps of ketamine's action, trough NMDA receptors, shared by both ketamine's clinical effects.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FL - Psychiatry, sexology

OECD FORD branch

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Project

<a href="/en/project/NT13403" target="_blank" >NT13403: The role of mTOR (mammalian target of rapamycin) pathway in the antidepressive effect of ketamine and antidepressive drugs in patient with depressive disorder: translation study</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Activitas Nervosa Superior Rediviva

ISSN

1337-933X

e-ISSN

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Volume of the periodical

55

Issue of the periodical within the volume

1-2

Country of publishing house

SK - SLOVAKIA

Number of pages

7

Pages from-to

57-63

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-84886264704