Agomelatine in generalized anxiety disorder: an active comparator and placebo-controlled study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F14%3A43914658" target="_blank" >RIV/00023752:_____/14:43914658 - isvavai.cz</a>
Result on the web
<a href="http://www.psychiatrist.com/JCP/article/Pages/2014/v75n04/v75n0411.aspx" target="_blank" >http://www.psychiatrist.com/JCP/article/Pages/2014/v75n04/v75n0411.aspx</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4088/JCP.13m08433" target="_blank" >10.4088/JCP.13m08433</a>

Result language
angličtina
Original language name
Agomelatine in generalized anxiety disorder: an active comparator and placebo-controlled study
Original language description
Agomelatine was efficacious in reducing symptoms in a short-term placebo-controlled trial in GAD and in preventing relapse in a longer term placebo-controlled study. An additional short-term placebo-controlled study is required by regulatory agencies toconfirm the efficacy of agomelatine in GAD. This 12-week, placebo-controlled, double-blind, randomized, parallel group, international, multicenter study was designed to confirm the efficacy of agomelatine 25-50 mg/d in the treatment of patients with a primary DSM-IV-TR diagnosis of GAD. The primary outcome measure was the (HARS) total score. Assay sensitivity was evaluated by including an escitalopram (10-20 mg/d) group. The study was undertaken in 45 clinical centers from April 2010 to July 2011. One hundred thirty-nine outpatients were included in the agomelatine group, 131 in the placebo group, and 142 in the escitalopram group. Agomelatine significantly reduced mean (SD) HARS total score (agomelatine-placebo difference: 4.71 [1.03],
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FL - Psychiatry, sexology
OECD FORD branch
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Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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