Differences between Tg2576 and wild type mice in the NMDA receptor-nitric oxide pathway after prolonged application of a diet high in advanced glycation end products

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F15%3A43914751" target="_blank" >RIV/00023752:_____/15:43914751 - isvavai.cz</a>
Result on the web
<a href="http://link.springer.com/article/10.1007%2Fs11064-015-1654-6" target="_blank" >http://link.springer.com/article/10.1007%2Fs11064-015-1654-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11064-015-1654-6" target="_blank" >10.1007/s11064-015-1654-6</a>

Result language
angličtina
Original language name
Differences between Tg2576 and wild type mice in the NMDA receptor-nitric oxide pathway after prolonged application of a diet high in advanced glycation end products
Original language description
Advanced glycation end AGE products, via cognate receptor activation, seem to be implicated in Alzheimer's disease. The NMDA receptor-nitric oxide pathway is influenced by AGE products and involved in the pathogenesis of this type of dementia. In this study, C57BL/6J (WT) and transgenic (Tg2576) mice expressing human mutant amyloid precursor protein were kept on prolonged (8 months) diets containing regular or high amounts of AGE products. After the decapitation of 11-months old mice, brain tissue analyses were performed [expressions of the NR1, NR2A and NR2B subunits of NMDA receptors, activities of neuronal, endothelial and inducible nitric oxide synthase (nNOS, eNOS and iNOS)]. Moreover, levels of malondialdehyde and of human amyloid beta 1-42 wereestimated. We found increased activity of nNOS in WT mice maintained on a high compared to regular AGE diet; however, no similar differences were found in Tg2576 mice. In addition, we observed an increase in NR1 expression in Tg2576 compa
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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