Quantitative assessment of motor speech abnormalities in idiopathic rapid eye movement sleep behaviour disorder
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F16%3A43914895" target="_blank" >RIV/00023752:_____/16:43914895 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21230/16:00243229 RIV/00216208:11110/16:10324199 RIV/00064165:_____/16:10324199
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S1389945715009296" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1389945715009296</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.sleep.2015.07.030" target="_blank" >10.1016/j.sleep.2015.07.030</a>
Alternative languages
Result language
angličtina
Original language name
Quantitative assessment of motor speech abnormalities in idiopathic rapid eye movement sleep behaviour disorder
Original language description
Objective: Patients with idiopathic rapid eye movement sleep behaviour disorder (RBD) are at substantial risk for developing Parkinson's disease (PD) or related neurodegenerative disorders. Speech is an important indicator of motor function and movement coordination, and therefore may be an extremely sensitive early marker of changes due to prodromal neurodegeneration. Methods: Speech data were acquired from 16 RBD subjects and 16 age- and sex-matched healthy control subjects. Objective acoustic assessment of 15 speech dimensions representing various phonatory, articulatory, and prosodic deviations was performed. Statistical models were applied to characterise speech disorders in RBD and to estimate sensitivity and specificity in differentiating between RBD and control subjects. Results: Some form of speech impairment was revealed in 88% of RBD subjects. Articulatory deficits were the most prominent findings in RBD. In comparison to controls, the RBD group showed significant alterations in irregular alternatingmotion rates (p = 0.009) and articulatory decay (p = 0.01). The combination of four distinctive speech dimensions, including aperiodicity, irregular alternating motion rates, articulatory decay, and dysfluency, led to 96% sensitivity and 79% specificity in discriminating between RBD and control subjects. Speech impairment was significantly more pronounced in RBD subjects with the motor score of the Unified Parkinson's Disease Rating Scale greater than 4 points when compared to other RBD individuals. Conclusion: Simple quantitative speech motor measures may be suitable for the reliable detection of prodromal neurodegeneration in subjects with RBD, and thereforemay provide important outcomes for future therapy trials.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FL - Psychiatry, sexology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NV15-28038A" target="_blank" >NV15-28038A: Speech disorders and analysis of their mechanisms in Parkinson's disease and other movement disorders.</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Sleep Medicine
ISSN
1389-9457
e-ISSN
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Volume of the periodical
19
Issue of the periodical within the volume
March
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
141-147
UT code for WoS article
000376518600023
EID of the result in the Scopus database
2-s2.0-84944145527