Cognitive deficits in patients with obsessive-compulsive disorder - electroencephalography correlates
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F16%3A43915006" target="_blank" >RIV/00023752:_____/16:43915006 - isvavai.cz</a>
Result on the web
<a href="https://www.dovepress.com/cognitive-deficits-in-patients-with-obsessivendashcompulsive-disorder--peer-reviewed-article-NDT" target="_blank" >https://www.dovepress.com/cognitive-deficits-in-patients-with-obsessivendashcompulsive-disorder--peer-reviewed-article-NDT</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2147/NDT.S93040" target="_blank" >10.2147/NDT.S93040</a>
Alternative languages
Result language
angličtina
Original language name
Cognitive deficits in patients with obsessive-compulsive disorder - electroencephalography correlates
Original language description
Background: Obsessive-compulsive disorder (OCD) is associated with cognitive dysfunction. Although there are several studies focused on the neurobiology of OCD, little is known about the biological correlates of the cognitive deficit linked to this disorder. The aim of our study was to examine the association between cognitive impairment and current source density markers in patients with OCD. Methods: Resting-state eyes-closed electroencephalography (EEG) data were recorded in 20 patients with OCD and 15 healthy controls who were involved in the study. Cortical EEG sources were estimated by standardized low-resolution electromagnetic tomography in seven frequency bands: delta (1.5-6 Hz), theta (6.5-8 Hz), alpha-1 (8.5-10 Hz), alpha-2 (10.5-12 Hz), beta-1 (12.5-18 Hz), beta-2 (18.5-21 Hz), and beta-3 (21.5-30 Hz). Cognitive performance was measured by the Trail-Making Test (versions A and B), Stroop CW Test, and D2 Test. Results: Frontal delta and theta EEG sources showed significantly higher activity in the whole group of patients with OCD (N=20) than in control subjects (N=15). Subsequent analysis revealed that this excess of low-frequency activity was present only in the subgroup of eleven patients with cognitive impairment (based on the performance in the Trail-Making Test - A). The subgroup of patients with normal cognitive functions (N=9) did not differ in cortical EEG sources from healthy controls. Conclusion: The present results suggest that frontal low-frequency cortical sources of resting-state EEG rhythms can distinguish groups of cognitively impaired and cognitively intact patients with OCD. Based on our results, future studies should consider whether the present methodological approach provides clinically useful information for the revelation of cognitive impairment in patients with OCD.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neuropsychiatric Disease and Treatment
ISSN
1178-2021
e-ISSN
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Volume of the periodical
12
Issue of the periodical within the volume
May
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
1119-1125
UT code for WoS article
000375536900001
EID of the result in the Scopus database
2-s2.0-84966318938