Topological properties of functional brain connectivity in obsessive-compulsive disorder

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F16%3A43915047" target="_blank" >RIV/00023752:_____/16:43915047 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21230/16:00242863 RIV/68407700:21730/16:00242863

Result on the web

<a href="http://link.springer.com/chapter/10.1007%2F978-3-319-32703-7_32" target="_blank" >http://link.springer.com/chapter/10.1007%2F978-3-319-32703-7_32</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-319-32703-7_32" target="_blank" >10.1007/978-3-319-32703-7_32</a>

Result language

angličtina

Original language name

Topological properties of functional brain connectivity in obsessive-compulsive disorder

Original language description

The paper is devoted to graph theoretical analysis of functional connectivity matrices of 96 patients diagnosed with obsessive-compulsive disorder (OCD) and 95 healthy controls. Connectivity matrices were obtained from electroencephalography (EEG) as a solution of inverse problem, each matrix contains functional connectivity of 84 regions of interest (ROIs) corresponding to segmentation according to the Brodmann areas. The connectivity matrix was converted into a graph by applying a threshold. Small-network characteristics such as clustering coefficient and characteristic path length were computed as a function of threshold for 4 frequency bands. It was shown that the level of clustering coefficient is significantly lower for the OCD group than for healthy controls, which means loss in local integration. Characteristic path length for OCD patients was significantly higher than for controls, which indicates loss in multi-scale connections. Regression analysis was used for understanding connection between topological features of the network and severity symptoms evaluated by the Yale-Brown Obsessive-Compulsive scale (Y-BOC). Direct relation was demonstrated between the severity of the disease and local integration properties in theta band (corelation coefficient 0.1870, p-value 0.018208).

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

AN - Psychology

OECD FORD branch

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Project

<a href="/en/project/ED2.1.00%2F03.0078" target="_blank" >ED2.1.00/03.0078: National institute of Mental Health</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016

ISBN

978-3-319-32701-3

ISSN

1680-0737

e-ISSN

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Number of pages

5

Pages from-to

157-161

Publisher name

Springer Nature

Place of publication

Switzerland

Event location

Paphose, Cyprus

Event date

Mar 31, 2016

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

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