Naturally occurring antibodies against synthetic fragment of neurotrophin receptor P75 in sera of cognitively impaired patients

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F16%3A43915204" target="_blank" >RIV/00023752:_____/16:43915204 - isvavai.cz</a>
Result on the web
<a href="http://www.symbiosisonlinepublishing.com/immunology/immunology49.pdf" target="_blank" >http://www.symbiosisonlinepublishing.com/immunology/immunology49.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.15226/2372-0948/4/2/00149" target="_blank" >10.15226/2372-0948/4/2/00149</a>

Result language
angličtina
Original language name
Naturally occurring antibodies against synthetic fragment of neurotrophin receptor P75 in sera of cognitively impaired patients
Original language description
Alzheimer’s disease is characterized by extracellular inclusions of beta-amyloid peptide. This peptide interacts with neuronal receptors in the human brain such as neurotrophin receptor P75 and neuronal acetylcholine receptor (nAChR) α7-type and pulls them down into plaques. Degraded receptors may introduce new antigenic epitopes to be recognized by specific antibodies in AD patients. The aim of the present work was to estimate the levels of the naturally occurring antibodies against two peptides derived from neuronal receptors –P75 and α7-type nAChR in sera of patients with different cognitive impairment.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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