The role of steroids in the prediction of affective disorders in adult men

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F17%3A43915346" target="_blank" >RIV/00023752:_____/17:43915346 - isvavai.cz</a>
Alternative codes found
RIV/00023761:_____/17:N0000021
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0039128X16301672" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0039128X16301672</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.steroids.2016.11.004" target="_blank" >10.1016/j.steroids.2016.11.004</a>

Result language
angličtina
Original language name
The role of steroids in the prediction of affective disorders in adult men
Original language description
Objective: Anxiety and mood disorders (AMD) are the most frequent mental disorders in the human population. They have recently shown increasing prevalence, and commonly disrupt personal and working lives. The aim of our study was to analyze the spectrum of circulating steroids in order to discover differences that could potentially be markers of affective depression or anxiety, and identify which steroids could be a predictive component for these diseases. Methods: We studied the steroid metabolome including 47 analytes in 20 men with depression (group D), 20 men with anxiety (group AN) and 30 healthy controls. OPLS and multivariate regression models were used for statistical analysis. Results: Discrimination of group D from controls by the OPLS method was absolute, as was group AN from controls (sensitivity = 1.000 (0.839, 1.000), specificity = 1.000 (0.887, 1.000)). Relatively good predictivity was also found for discrimination between group D from AN (sensitivity = 0.850 (0.640, 0.948), specificity = 0.900 (0.699, 0.972). Conclusion: Selected circulating steroids, including those that are neuroactive and neuroprotective, can be useful tools for discriminating between these affective diseases in adult men.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30215 - Psychiatry

Project
<a href="/en/project/NT13890" target="_blank" >NT13890: The role of neuroactive steroids in etiopathogenesis of mood and anxiety disorders</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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