Psychiatric disorders and quality of life in the offspring of parents with bipolar disorder

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F17%3A43918988" target="_blank" >RIV/00023752:_____/17:43918988 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/17:10363834 RIV/00216208:11120/17:43915288 RIV/00216208:11130/17:10363834 RIV/00064203:_____/17:10363834 RIV/00064165:_____/17:10363834

Result on the web

<a href="http://online.liebertpub.com/doi/10.1089/cap.2016.0056" target="_blank" >http://online.liebertpub.com/doi/10.1089/cap.2016.0056</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1089/cap.2016.0056" target="_blank" >10.1089/cap.2016.0056</a>

Result language

angličtina

Original language name

Psychiatric disorders and quality of life in the offspring of parents with bipolar disorder

Original language description

Objective: To determine current and lifetime psychopathology and assess quality of life (QoL) in offspring of a parent with bipolar disorder (BD). Methods: We investigated 43 offspring of bipolar parents (high-risk offspring [HRO]) (mean age 12.5 – 3.1; range 6.7–17.9 years) and 43 comparison offspring matched for sex, age, and IQ of healthy parents. Lifetime and current presence of Diagnostic and Statistical Manual of Mental Disorders, 5th ed. (DSM-5) diagnoses were assessed using Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version (K-SADS-PL). We administered parent and self-report versions of General Behavior Inventory and the Screen for Child Anxiety-Related Emotional Disorders (SCARED). QoL was evaluated using the self-report questionnaire KIDSCREN-52. Results: Thirty-seven HRO (86%) and 18 controls (42%) met DSM-5 criteria for at least one lifetime psychiatric diagnosis (adjusted OR= 7.20; 95% CI 2.27–22.81). Compared to controls, HRO had higher lifetime frequency of any mood disorder (33% vs. 2%, p &lt; 0.001), anxiety disorder (60% vs. 14%, p &lt; 0.001), and attention-deficit/hyperactivity disorder (26% vs. 5%, p = 0.01). After adjustment for confounders, only mood (OR = 13.05; 95% CI 1.41–120.60) and anxiety (OR = 9.69; 95% CI 2.75–34.31) disorders remained significantly more frequent in the HRO group. In comparison with controls, HRO scored lower in the following domains: QoL, social support and relationship with peers ( p = 0.003; Cohen’s d = 0.91), parent relationships and home life ( p = 0.008; d = 0.67), as well as self-perception ( p = 0.04; d = 0.55). Conclusions: In agreement with other studies, we found a higher rate of lifetime anxiety and mood disorders in children and adolescents at confirmed familial risk for BD. Reduction in QoL was already evident across a number of domains. Adult psychiatrists should incorporate into their assessment procedures targeted questions on the presence of psychopathology in offspring of their adult patients with severe mental disorders and child services should bridge with adult services providing accessible services to children of affected parents.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30215 - Psychiatry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Child and Adolescent Psychopharmacology

ISSN

1044-5463

e-ISSN

—

Volume of the periodical

27

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

483-493

UT code for WoS article

000407894800003

EID of the result in the Scopus database

2-s2.0-85027885952