Impairment of neural coordination in hippocampal neuronal ensembles after a psychotomimetic dose of dizocilpine

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F18%3A43919060" target="_blank" >RIV/00023752:_____/18:43919060 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/18:00489341

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S0278584617302464?via%3Dihub" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0278584617302464?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.pnpbp.2017.09.013" target="_blank" >10.1016/j.pnpbp.2017.09.013</a>

Result language

angličtina

Original language name

Impairment of neural coordination in hippocampal neuronal ensembles after a psychotomimetic dose of dizocilpine

Original language description

The discoordination hypothesis of schizophrenia posits discoordination of neural activity as the central mechanism that underlies some psychotic symptoms (including ‘hallmark’ cognitive symptoms) of schizophrenia. To test this proposition, we studied the activity of hippocampal neurons in urethane anesthetized Long Evans rats after 0.15 mg/kg dizocilpine (MK-801), an N-Methyl-D-aspartate (NMDA) glutamate receptor antagonist, which can cause psychotic symptoms in humans and cognitive control impairments in animals. We observed that MK-801 altered the temporal coordination, but not rate, of neuronal firing. Coactivation between neurons increased, driven primarily by increased coincident firing of cell pairs that did not originally fire together before MK-801 injection. Increased pairwise coactivation manifested as disorganized discharge on the level of neuronal ensembles, which in turn could lead to disorganization in information processing. Disorganization of neuronal activity after a psychotomimetic dose of MK-801 supports the discoordination hypothesis of psychosis.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Progress in Neuro-Psychopharmacology &amp; Biological Psychiatry

ISSN

0278-5846

e-ISSN

—

Volume of the periodical

81

Issue of the periodical within the volume

February

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

275-283

UT code for WoS article

000414901100032

EID of the result in the Scopus database

2-s2.0-85029675626