Treatment of atrial fibrillation in patients with dementia: a cohort Study from the Swedish dementia registry

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F18%3A43919201" target="_blank" >RIV/00023752:_____/18:43919201 - isvavai.cz</a>

Result on the web

<a href="https://content.iospress.com/articles/journal-of-alzheimers-disease/jad170575" target="_blank" >https://content.iospress.com/articles/journal-of-alzheimers-disease/jad170575</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3233/JAD-170575" target="_blank" >10.3233/JAD-170575</a>

Result language

angličtina

Original language name

Treatment of atrial fibrillation in patients with dementia: a cohort Study from the Swedish dementia registry

Original language description

Patients with dementia might have higher risk for hemorrhagic complications with anticoagulant therapy prescribed for atrial fibrillation (AF). This study assesses the risks and benefits of warfarin, antiplatelets, and no treatment in patients with dementia and AF. Of 49,792 patients registered in the Swedish Dementia Registry 2007-2014, 8,096 (16%) had a previous diagnosis of AF. Cox proportional hazards models were used to calculate the risk for ischemic stroke (IS), nontraumatic intracranial hemorrhage, any-cause hemorrhage, and death. Out of the 8,096 dementia patients with AF, 2,143 (26%) received warfarin treatment, 2,975 (37%) antiplatelet treatment, and 2,978 (37%) had no antithrombotic treatment at the time of dementia diagnosis. Patients on warfarin had fewer IS than those IS without treatment (5.2% versus 8.7%; p &lt; 0.001) with no differences compared to antiplatelets. In adjusted analyses, warfarin was associated with a lower risk for IS (HR 0.76, CI 0.59-0.98), while antiplatelets were associated with increased risk (HR 1.25, CI 1.01-1.54) compared to no treatment. For any-cause hemorrhage, there was a higher risk with warfarin (HR 1.28, CI 1.03-1.59) compared to antiplatelets. Warfarin and antiplatelets were associated with a lower risk for death compared to no treatment. Warfarin treatment in Swedish patients with dementia is associated with lower risk of IS and mortality, and a small increase in any-cause hemorrhage. This study supports the use of warfarin in appropriate cases in patients with dementia. The low percentage of patients on warfarin treatment indicates that further gains in stroke prevention are possible.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30227 - Geriatrics and gerontology

Project

<a href="/en/project/LO1611" target="_blank" >LO1611: Sustainability for The National Institute of Mental Health</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Alzheimer´s Disease

ISSN

1387-2877

e-ISSN

—

Volume of the periodical

61

Issue of the periodical within the volume

3

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

10

Pages from-to

1119-1128

UT code for WoS article

000422845200025

EID of the result in the Scopus database

2-s2.0-85044294974