Magnetic resonance imaging showing parietal atrophy of the brain in lateonset Alzheimer’s disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F19%3A43919809" target="_blank" >RIV/00023752:_____/19:43919809 - isvavai.cz</a>

Result on the web

<a href="https://www.csnn.eu/casopisy/ceska-slovenska-neurologie/2019-1-2/parietalni-atrofie-na-magneticke-rezonanci-mozku-u-alzheimerovy-nemoci-s-pozdnim-zacatkem-107572" target="_blank" >https://www.csnn.eu/casopisy/ceska-slovenska-neurologie/2019-1-2/parietalni-atrofie-na-magneticke-rezonanci-mozku-u-alzheimerovy-nemoci-s-pozdnim-zacatkem-107572</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14735/amcsnn201991" target="_blank" >10.14735/amcsnn201991</a>

Result language

angličtina

Original language name

Magnetic resonance imaging showing parietal atrophy of the brain in lateonset Alzheimer’s disease

Original language description

Aim: Our intention was to assess whether a scoring of parietal atrophy on MRI of the brain using a simple visual assessment named PAS (Parietal Atrophy Score) could be used in the diagnosis of late-onset Alzheimer‘s disease. Patients and methods: The structure of the parietal lobes was evaluated by our visual scale named PAS, which is based on semiquantitative scoring of atrophy of three structures in the parietal region: sulcus cingularis posterior, precuneus and parietal gyri. Parietal atrophy was assessed in 24 patients with late-onset Alzheimer‘s disease in the stage of mild dementia (Mini-Mental State Examination; MMSE 21 ± 3 points) and 26 age-matched individuals with normal scores on the MMSE (29 ± 1 point). Results: We did not find any statistically significant difference in the size of any structure of the right and left parietal lobe according to the PAS visual scale between control individuals and patients with Alzheimer‘s disease (p &gt; 0.05 in all cases). Conclusion: During late-onset Alzheimer‘s disease there is no significant reduction of parietal cortex until the stage of mild dementia compared to normal aging. Parietal atrophy evaluated according to the PAS visual scale is not an appropriate marker to be used in the diagnosis of late-onset Alzheimer‘s disease in mild stages.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30210 - Clinical neurology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Česká a slovenská neurologie a neurochirurgie

ISSN

1802-4041

e-ISSN

—

Volume of the periodical

82

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

91-95

UT code for WoS article

000458015800012

EID of the result in the Scopus database

2-s2.0-85066997026