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Neuropsychological functioning and temperament traits in a Czech sample of children and adolescents at familial risk of bipolar disorder

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F19%3A43919824" target="_blank" >RIV/00023752:_____/19:43919824 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/19:10393532 RIV/00216208:11120/19:43918070 RIV/00216208:11130/19:10393532 RIV/00064203:_____/19:10393532

  • Result on the web

    <a href="https://www.frontiersin.org/articles/10.3389/fpsyt.2019.00198/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fpsyt.2019.00198/full</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3389/fpsyt.2019.00198" target="_blank" >10.3389/fpsyt.2019.00198</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Neuropsychological functioning and temperament traits in a Czech sample of children and adolescents at familial risk of bipolar disorder

  • Original language description

    Background: Although a positive family history is the strongest predictor for bipolar disorder (BD), most offspring of BD parents (BO) will not develop the disorder. Identification of vulnerability markers for BD is essential for specific individual risk estimation. Impairments in cognitive functioning and the presence of specific temperament traits are considered promising candidates. Methods: Sixty-three BO (48% female; 11.8 ± 3.3 years) and 54 control offspring (CO; 44% female; 12.3 ± 3.2 years) comparable in sex (p = 0.4) and age (p = 0.4) were enrolled. Detection of current sub/threshold mood symptoms by the Kiddie Schedule for Affective Disorders and Schizophrenia and General Behavior Inventory was applied to separate BO into ultrahigh-risk (UHR) and high-risk (HR) subgroups. Cognitive functions were tested by the Developmental Neuropsychological Assessment II test battery, d2 Test of Attention, and Amsterdam Neuropsychological Tasks. Temperament was assessed by the Temperament in Middle Childhood and Early Adolescent Temperament Questionnaires. Results: The BO sample consisted of 5 BD, 17 UHR, and 41 HR participants. We did not observe any significant differences between the BO and CO groups or between the UHR, HR, and CO subgroups (Hedges&apos; g = 0.21–0.39) in cognitive functioning. The BO differed significantly in some temperament traits from the CO (g = 0.42–0.61), while the UHR subgroup exhibited lower effortful control and attention focusing than both HR and CO participants (g = 0.92–1.19). Limitations: The cross-sectional design and wide age range of the sample limited our findings. Conclusions: Neuropsychological impairment does not seem to be a trait marker of BD in the premorbid stage. Temperament with low effortful control and low attention focusing might be associated with the development of mood disorders in BO.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30215 - Psychiatry

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Frontiers in Psychiatry

  • ISSN

    1664-0640

  • e-ISSN

  • Volume of the periodical

    10

  • Issue of the periodical within the volume

    April

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    11

  • Pages from-to

    "Article Number: 198"

  • UT code for WoS article

    000463940200001

  • EID of the result in the Scopus database

    2-s2.0-85067966554