Neuropsychological functioning and temperament traits in a Czech sample of children and adolescents at familial risk of bipolar disorder
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F19%3A43919824" target="_blank" >RIV/00023752:_____/19:43919824 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10393532 RIV/00216208:11120/19:43918070 RIV/00216208:11130/19:10393532 RIV/00064203:_____/19:10393532
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fpsyt.2019.00198/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fpsyt.2019.00198/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fpsyt.2019.00198" target="_blank" >10.3389/fpsyt.2019.00198</a>
Alternative languages
Result language
angličtina
Original language name
Neuropsychological functioning and temperament traits in a Czech sample of children and adolescents at familial risk of bipolar disorder
Original language description
Background: Although a positive family history is the strongest predictor for bipolar disorder (BD), most offspring of BD parents (BO) will not develop the disorder. Identification of vulnerability markers for BD is essential for specific individual risk estimation. Impairments in cognitive functioning and the presence of specific temperament traits are considered promising candidates. Methods: Sixty-three BO (48% female; 11.8 ± 3.3 years) and 54 control offspring (CO; 44% female; 12.3 ± 3.2 years) comparable in sex (p = 0.4) and age (p = 0.4) were enrolled. Detection of current sub/threshold mood symptoms by the Kiddie Schedule for Affective Disorders and Schizophrenia and General Behavior Inventory was applied to separate BO into ultrahigh-risk (UHR) and high-risk (HR) subgroups. Cognitive functions were tested by the Developmental Neuropsychological Assessment II test battery, d2 Test of Attention, and Amsterdam Neuropsychological Tasks. Temperament was assessed by the Temperament in Middle Childhood and Early Adolescent Temperament Questionnaires. Results: The BO sample consisted of 5 BD, 17 UHR, and 41 HR participants. We did not observe any significant differences between the BO and CO groups or between the UHR, HR, and CO subgroups (Hedges' g = 0.21–0.39) in cognitive functioning. The BO differed significantly in some temperament traits from the CO (g = 0.42–0.61), while the UHR subgroup exhibited lower effortful control and attention focusing than both HR and CO participants (g = 0.92–1.19). Limitations: The cross-sectional design and wide age range of the sample limited our findings. Conclusions: Neuropsychological impairment does not seem to be a trait marker of BD in the premorbid stage. Temperament with low effortful control and low attention focusing might be associated with the development of mood disorders in BO.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30215 - Psychiatry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Psychiatry
ISSN
1664-0640
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
April
Country of publishing house
CH - SWITZERLAND
Number of pages
11
Pages from-to
"Article Number: 198"
UT code for WoS article
000463940200001
EID of the result in the Scopus database
2-s2.0-85067966554