Holocaust history is not reflected in telomere homeostasis in survivors and their offspring

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F19%3A43920183" target="_blank" >RIV/00023752:_____/19:43920183 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14740/19:00108514

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S002239561930161X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S002239561930161X?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jpsychires.2019.06.018" target="_blank" >10.1016/j.jpsychires.2019.06.018</a>

Result language

angličtina

Original language name

Holocaust history is not reflected in telomere homeostasis in survivors and their offspring

Original language description

Telomeres, nucleoprotein structures at the ends of eukaryotic chromosomes, are crucial for the maintenance of genome integrity. While the lengths of telomeres at birth are determined genetically, many factors including environmental and living conditions affect the telomere lengths during a lifespan. In this context, extreme and long-term stress has been shown to negatively impact telomeres and their protective function, with even offspring being influenced by the stress experienced by parents. Using quantitative PCR, the relative lengths of telomeres of survivors of the Holocaust during World War II and two generations of their offspring were analyzed. These data were related to those of control groups, persons of comparable age without a strong life stress experience. In contrast to previous studies of other stress-exposed groups, the relative lengths of telomeres were comparable in groups of persons exposed to Holocaust-related stress and their progenies, and in control groups. Interestingly, shorter telomeres of Holocaust survivors of the age under 12 in the year 1945 compared to Holocaust survivors of the age above 12 were detected. Our results are discussed with respect to certain exceptionality of persons having been able to cope with an extreme stress more than 70 years ago and living to a very old age.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30215 - Psychiatry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Psychiatric Research

ISSN

0022-3956

e-ISSN

—

Volume of the periodical

117

Issue of the periodical within the volume

October

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

7-14

UT code for WoS article

000484872500002

EID of the result in the Scopus database

2-s2.0-85067844655