Nonlinear Measure of EEG Complexity in the Eker Rat Model of Autism Disorder - a Pilot Study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F20%3A43920282" target="_blank" >RIV/00023752:_____/20:43920282 - isvavai.cz</a>
Result on the web
<a href="https://dl.acm.org/doi/10.1145/3409915.3409927" target="_blank" >https://dl.acm.org/doi/10.1145/3409915.3409927</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Nonlinear Measure of EEG Complexity in the Eker Rat Model of Autism Disorder - a Pilot Study
Original language description
Tuberous Sclerosis Complex (TSC) is a severe pathological condition often accompanied by Autism Spectrum Disorder (ASD) and epilepsy. Recently, conclusions resulting from exploration of animal models suggested inhibition of mTOR to be a potential effective treatment. The EEG activity in Tsc2+/- (Eker) rat model has never been explored before. In this pilot study, we performed nonlinear EEG analysis to characterize its significant alterations resulting from treatment based on mTORi (inhibition of mammalian target of rapamycin), as well as from induction of developmental status epilepticus (DSE). Our results based of approximate entropy calculations confirmed that Everolimu (mTOR inhibitor) has a different influence on the regularity of EEG oscillations in wild-type and Tsc2+/- individuals. Moreover, we did not observe any alteration of EEG pattern complexity in adult rats with a history of DSE, and conclude that genotype (Tsc2+/-) and DSE state are probably influenced by different mechanisms of mTORi, with potential for clinical practice.
Czech name
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Czech description
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Project
<a href="/en/project/LO1611" target="_blank" >LO1611: Sustainability for The National Institute of Mental Health</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
2nd International Applied Mathematics, Modelling and Simulation Conference (AMMS 2020); June 21-23, 2020
ISBN
978-1-4503-7541-2
ISSN
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e-ISSN
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Number of pages
5
Pages from-to
49-53
Publisher name
ACM International Conference Proceeding
Place of publication
New York
Event location
Paris
Event date
Jun 21, 2020
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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