Repetitive transcranial magnetic stimulation (rTMS) for schizophrenia patients treated with clozapine

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F21%3A43920198" target="_blank" >RIV/00023752:_____/21:43920198 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/21:43920030

Result on the web

<a href="https://www.tandfonline.com/doi/full/10.1080/15622975.2020.1733080" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/15622975.2020.1733080</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/15622975.2020.1733080" target="_blank" >10.1080/15622975.2020.1733080</a>

Result language

angličtina

Original language name

Repetitive transcranial magnetic stimulation (rTMS) for schizophrenia patients treated with clozapine

Original language description

Objectives: Biological strategies to improve treatment efficacy in clozapine-treated patients are urgently needed. Repetitive transcranial magnetic stimulation (rTMS) merits consideration as intervention for patients with persistent auditory hallucinations (AH) or negative symptoms (NS) not responding sufficiently to clozapine treatment. Methods: Data from 10 international RCTs of rTMS for patients being treated with clozapine were pooled. Two levels of symptomatic response were defined: improvement of ≥20% and ≥50% on study-specific primary endpoint scales. Changes in the positive and negative syndrome scale (PANSS) from baseline to endpoint assessment were also analysed. Results: Analyses of 131 patients did not reveal a significant difference for ≥20% and ≥50% response thresholds for improvement of AH, negative or total symptoms between active and sham rTMS groups. The number needed to treat (NNT) for an improvement in persistent AH was nine following active rTMS. PANSS scores did not improve significantly from baseline to endpoint between active and sham groups in studies investigating NS and AH. Conclusions: rTMS as a treatment for persistent symptoms in clozapine-treated patients did not show a beneficial effect of active compared to sham treatment. For AH, the size of the NNTs indicates a possible beneficial effect of rTMS.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30215 - Psychiatry

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

World Journal of Biological Psychiatry

ISSN

1562-2975

e-ISSN

—

Volume of the periodical

22

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

14-26

UT code for WoS article

000519640300001

EID of the result in the Scopus database

2-s2.0-85081726819