Long-term cognitive trajectory and activities of daily living in healthy aging
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F21%3A43920229" target="_blank" >RIV/00023752:_____/21:43920229 - isvavai.cz</a>
Alternative codes found
RIV/67985807:_____/21:00523887 RIV/00216208:11120/21:43920087 RIV/00023884:_____/21:00009225 RIV/00216208:11110/21:10410634 RIV/00064165:_____/21:10410634
Result on the web
<a href="https://www.tandfonline.com/doi/full/10.1080/13854046.2020.1745895" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/13854046.2020.1745895</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/13854046.2020.1745895" target="_blank" >10.1080/13854046.2020.1745895</a>
Alternative languages
Result language
angličtina
Original language name
Long-term cognitive trajectory and activities of daily living in healthy aging
Original language description
Objective: The purpose of the present study was to investigate if participants in NANOK study (National Normative Study of Cognitive Determinants of Healthy Ageing) who show no cognitive decline throughout five years (successful healthy agers; SHA) will show less age-related differences in instrumental activities of daily living (IADL) based on Functional Activities Questionnaire in comparison to participants who show subtle cognitive decline (Decliners) over time. Method: We used two different classifications of SHA: Rogalski (N = 25 SHA and N = 15 Decliners) based on cross-sectional neuropsychology measures and linear mixed model (LMEM; 20 SHA and 20 Decliners) based on the Montreal Cognitive Assessment longitudinal 5-years follow-up. Whole-brain T1- and T2-weighted images were corrected for distortions and segmented using Freesurfer. Whole-brain volumetry was performed using FSL’s voxel-based morphometry tool. Results: The cognitive decline after four years follow-up but not age predicts subtle impairment in IADL in healthy ageing participants. We found brain volumetric differences between SHA and Decliners based on Rogalski but not LMEM classification especially in bilateral insular cortices and ventrolateral frontal cortex. The logistic regression model achieved an accuracy of 75% for the Rogalski in comparison to 67.5% for the LMEM classification. Conclusions: Slight restrictions in IADL seem to be a useful tool for screening healthy ageing participants at risk of developing subtle cognitive decline over a period of five years and the cross-sectional Rogalski criteria based on standardized neuropsychological measures were superior for tapping age-related brain changes to longitudinal LMEM classification based on screening (Montreal Cognitive Assessment).
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
50101 - Psychology (including human - machine relations)
Result continuities
Project
<a href="/en/project/GA16-01781S" target="_blank" >GA16-01781S: Cognitive predictors of neurodegeneration</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Neuropsychologist
ISSN
1385-4046
e-ISSN
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Volume of the periodical
35
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
17
Pages from-to
1381-1397
UT code for WoS article
000527258000001
EID of the result in the Scopus database
2-s2.0-85083634600