Predictive Value of Heart Rate in Treatment of Major Depression with Ketamine in Two Controlled Trials
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F21%3A43920534" target="_blank" >RIV/00023752:_____/21:43920534 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/21:43921421
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S138824572100081X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S138824572100081X?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.clinph.2021.01.030" target="_blank" >10.1016/j.clinph.2021.01.030</a>
Alternative languages
Result language
angličtina
Original language name
Predictive Value of Heart Rate in Treatment of Major Depression with Ketamine in Two Controlled Trials
Original language description
Objective: Ketamine has been shown to be effective in treatment of episodes of major depressive disorder (MDD). This controlled study aimed to analyse the predictive and discriminative power of heart rate (HR) and heart rate variability (HRV) for ketamine treatment in MDD. Methods: In 51 patients, HR and HRV were assessed at baseline before and during ketamine infusion and 24 hours post ketamine infusion. Montgomery–Åsberg Depression Rating Scale (MADRS) was used to assess changes of depressive symptoms. A 30% or 50% reduction of symptoms after 24 hours or within 7 days was defined as response. A linear mixed model was used for analysis. Results: Ketamine infusion increased HR and HRV power during and after infusion. Responders to ketamine showed a higher HR during the whole course of investigation, including at baseline with medium effect sizes (Cohen‘s d=0.47-0.67). Furthermore, HR and HRV power discriminated between responders and non-responders, while normalized low and high frequencies did not. Conclusion: The findings show a predictive value of HR and HRV power for ketamine treatment. This further underlines the importance of the autonomous nervous system (ANS) and its possible malfunctions in MDD. Significance: The predictive power of HR and HRV markers should be studied in prospective studies. Neurophysiological markers could improve treatment for MDD via optimizing the choice of treatments.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30215 - Psychiatry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Neurophysiology
ISSN
1388-2457
e-ISSN
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Volume of the periodical
132
Issue of the periodical within the volume
6
Country of publishing house
IE - IRELAND
Number of pages
8
Pages from-to
1339-1346
UT code for WoS article
000653018000023
EID of the result in the Scopus database
2-s2.0-85106084719