Tissue-specific protective properties of lithium: comparison of rat kidney, erythrocytes and brain
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F21%3A43920597" target="_blank" >RIV/00023752:_____/21:43920597 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/21:00542670
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs00210-020-02036-4" target="_blank" >https://link.springer.com/article/10.1007%2Fs00210-020-02036-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00210-020-02036-4" target="_blank" >10.1007/s00210-020-02036-4</a>
Alternative languages
Result language
angličtina
Original language name
Tissue-specific protective properties of lithium: comparison of rat kidney, erythrocytes and brain
Original language description
Lithium (Li) represents a first choice mood stabilizer for bipolar disorder (BD). Despite extensive clinical use, questions regarding its mechanism of action and pathological mechanism of renal function impairment by Li remain open. The present study aimed to improve our knowledge in this area paying special attention to the relationship between the length of Li action, lipid peroxidation (LP), and Na+/K+-ATPase properties. The effects of therapeutic Li doses, administered daily to male Wistar rats for 1 (acute), 7 (short term) and 28 days (chronic), were studied. For this purpose, Na+/K+-ATPase activity measurements, [3H]ouabain binding and immunoblot analysis of α-Na+/K+-ATPase were performed. Li-induced LP was evaluated by determining the malondialdehyde concentration by HPLC. Sleep deprivation (SD) was used as an experimental approach to model the manic phase of BD. Results obtained from the kidney were compared to those obtained from erythrocytes and different brain regions in the same tested animals. Whereas treatment with therapeutic Li concentration did not bring any LP damage nor significant changes of Na+/K+-ATPase expression and [3H]ouabain binding in the kidney, it conferred strong protection against this type of damage in the forebrain cortex. Importantly, the observed changes in erythrocytes indicated changes in forebrain cortices. Thus, different resistance to SD-induced changes of LP and Na+/K+-ATPase was detected in the kidney, erythrocytes and the brain of Li-treated rats. Our study revealed the tissue-specific protective properties of Li against LP and Na+/K+-ATPase regulation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30215 - Psychiatry
Result continuities
Project
<a href="/en/project/GA17-07070S" target="_blank" >GA17-07070S: Effect of lithium on Na+/K+-ATPase activity and functional consequences of oxidative stress; from animal model to bipolar patients</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Naunyn-Schmiedeberg's Archives of Pharmacology
ISSN
0028-1298
e-ISSN
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Volume of the periodical
394
Issue of the periodical within the volume
5
Country of publishing house
DE - GERMANY
Number of pages
11
Pages from-to
955-965
UT code for WoS article
000605531100002
EID of the result in the Scopus database
2-s2.0-85099065211