Open Access: The Effect of Neurorehabilitation on Multiple Sclerosis-Unlocking the Resting-State fMRI Data

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F21%3A43920598" target="_blank" >RIV/00023752:_____/21:43920598 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/21:43921671 RIV/68407700:21230/21:00350089

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fnins.2021.662784/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fnins.2021.662784/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fnins.2021.662784" target="_blank" >10.3389/fnins.2021.662784</a>

Result language

angličtina

Original language name

Open Access: The Effect of Neurorehabilitation on Multiple Sclerosis-Unlocking the Resting-State fMRI Data

Original language description

Multiple Sclerosis (MS) is a severe neurological condition, the incidence of which is growing on a global scale, reporting over 2.2million cases worldwide in 2016 (Wallin et al., 2019). The symptoms associated with the disease vary and include gait and postural control changes, problems with vision, sensory symptoms, cognitive decline, depression, and others (Kister et al., 2013). Despite the seriousness of the condition, its’ relative rareness and heterogeneity obstructs the neuroimaging research that could identify brain-dependent patterns that play a role in the disease’s progression. It has been shown that acute relapse or chronic insult in people with MS may stimulate brain plasticity mechanisms—the intrinsic cascades of the brain to functionally and structurally reorganize itself in response to external stimuli. However, a gradual failure of these processes to manage the increasing structural and functional changes caused by demyelination may eventually lead to impairment (Pascual-Leone et al., 2005; Prosperini et al., 2015). It has been hypothesized that by supporting the brain plasticity mechanisms via regular cognitive and motoric exercise, the progression of the disease might be slowed down. The positive effect of neurorehabilitation on brain activity has already been studied to some degree. Rasova et al. reported an increased correlation of fMRI activity among hemispheres following 2 months of eclectic rehabilitative therapy. Furthermore, they also found a decrease of effective connectivity at supplementary motor areas (Rasova et al., 2005, 2015). This evidence was later supported by other groups finding a beneficial functional reorganization in the sensory-motor network after motor rehabilitation (Tavazzi et al., 2018; Fling et al., 2019; Prochazkova et al., 2020). Tomassini et al. (2012) studied brain plasticity for visuomotor practice in MS patients and found it preserved despite the extent of cerebral pathology. Another study observed a correlation between motor improvements and fMRI modifications in MS patients after watching and imitating videos of daily life (Rocca et al., 2019). However, as pointed out in a recent review, most of the research in this domain suffers from the use of small sets of volunteers, which usually does not exceed twenty (Prosperini and Di Filippo, 2019). This raises concerns about the interpretation and generalization of reported findings, and makes the idea of sharing data more desirable (and eventually inevitable) to gain credibility. Considering the above, we share resting-state fMRI activity profiles across 60 people with MS before and after 2 months of neuroproprioceptive “facilitation and inhibition” treatment.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Neuroscience

ISSN

1662-453X

e-ISSN

—

Volume of the periodical

15

Issue of the periodical within the volume

"Article Number: 662784"

Country of publishing house

CH - SWITZERLAND

Number of pages

6

Pages from-to

1-6

UT code for WoS article

000659982200001

EID of the result in the Scopus database

2-s2.0-85107827082