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Neurostimulation Methods in the Treatment of Depression: A Comparison of rTMS, tDCS, and Venlafaxine Using a Pooled Analysis of Two Studies

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F21%3A43920609" target="_blank" >RIV/00023752:_____/21:43920609 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11120/21:43921734

  • Result on the web

    <a href="https://www.dovepress.com/neurostimulation-methods-in-the-treatment-of-depression-a-comparison-o-peer-reviewed-fulltext-article-NDT" target="_blank" >https://www.dovepress.com/neurostimulation-methods-in-the-treatment-of-depression-a-comparison-o-peer-reviewed-fulltext-article-NDT</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2147/NDT.S303226" target="_blank" >10.2147/NDT.S303226</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Neurostimulation Methods in the Treatment of Depression: A Comparison of rTMS, tDCS, and Venlafaxine Using a Pooled Analysis of Two Studies

  • Original language description

    Background: There are no head-to-head studies comparing the antidepressant effect of transcranial direct current stimulation (tDCS) with repetitive transcranial magnetic stimulation (rTMS). This pooled analysis compared indirectly the antidepressant efficacy and acceptability of rTMS, tDCS, and the antidepressant venlafaxine (VNF) extended-release. Methods: The analysis (n=117, both patients with treatment-resistant depression (TRD) and non-TRD were included) examined pooled data from two 4-week, single-centered, two-armed, double-blind, randomized studies (EUDRACT n. 2005-000826-22 and EUDRACT n. 2015-001639-19). The antidepressant efficacy of right-sided low-frequency rTMS (n=29) vs VNF (n=31) and left-sided anodal tDCS (n=29) vs VNF (n=28) was evaluated. The primary outcome was a change in the Montgomery–Åsberg Depression Rating Scale (MADRS) score from baseline to the treatment endpoint at week 4. The response was defined as a ≥ 50% reduction in the MADRS score and remission as the MADRS score ≤ 10 points, both were calculated for the primary treatment endpoint at week 4. Results: Mean change in total MADRS scores from baseline to week 4 was 7.0 (95% CI, 4.8– 9.1) points in the rTMS group, 7.6 (95% CI, 5.5– 9.8) in the tDCS group, and 8.9 (95% CI, 7.4– 10.4) among patients in the VNF group, a non-significant difference (F(2111)=0.62, p=0.54). Similarly, neither the response rates nor remission rates for rTMS (response 31%; remission 17%), tDCS (24%, 17%), or VNF (41%; 27%) significantly differed among treatment groups (χ2=2.59, p=0.28; χ2=1.66, p=0.44). Twenty patients (17%) dropped out of the studies in a similar proportion across groups (rTMS 3/29, tDCS 6/29, VNF 11/59, χ2=1.41, p=0.52). Conclusion: Our current analysis found a comparable efficacy and acceptability in all three treatment modalities (rTMS, tDCS, and VNF) and clinical relevance for the acute treatment of major depressive disorder.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30215 - Psychiatry

Result continuities

  • Project

    <a href="/en/project/NV18-04-00260" target="_blank" >NV18-04-00260: Clinical and neurobiological predictors of response to ketamine: towards personalized treatment of depression</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Neuropsychiatric Disease and Treatment

  • ISSN

    1178-2021

  • e-ISSN

  • Volume of the periodical

    2021

  • Issue of the periodical within the volume

    17

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    10

  • Pages from-to

    1713-1722

  • UT code for WoS article

    000659027300003

  • EID of the result in the Scopus database

    2-s2.0-85107838305