Effects of Transcranial Direct Current Stimulation Treatment for Anorexia Nervosa

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F21%3A43920690" target="_blank" >RIV/00023752:_____/21:43920690 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/21:43922460 RIV/00023761:_____/21:N0000004 RIV/00216208:11110/21:10433076 RIV/00064165:_____/21:10433076

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fpsyt.2021.717255/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fpsyt.2021.717255/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fpsyt.2021.717255" target="_blank" >10.3389/fpsyt.2021.717255</a>

Result language

angličtina

Original language name

Effects of Transcranial Direct Current Stimulation Treatment for Anorexia Nervosa

Original language description

Background: Anorexia nervosa (AN) is a life-threatening illness with poor treatment outcomes. Although transcranial direct current stimulation (tDCS) is a promising non-invasive brain stimulation method, its effect in patients with AN remains unclear. Objective: This study investigated changes in maladaptive eating behavior, body mass index (BMI), and depression after 10 sessions of anodal tDCS over the left dorsolateral prefrontal cortex (DLPFC). Methods: In this double-blind, randomized controlled trial, 43 inpatients with AN were divided to receive either active (n = 22) or sham (n = 21) tDCS over the left DLPFC (anode F3/cathode Fp2, 2 mA for 30 min). All patients filled the Eating Disorder Examination Questionnaire (EDE-Q) and Zung Self-Rating Depression Scale (ZUNG), and their BMI was measured. These values were obtained repeatedly in four stages: (1) before tDCS treatment, (2) after tDCS treatment, (3) in the follow-up after 2 weeks, and (4) in the follow-up after 4 weeks. Results: Primary outcomes (EDE-Q) based on the ANOVA results do not show any between-group differences either after the active part of the study or in the follow-up. Secondary analysis reveals a reduction in some items of EDE-Q. Compared with sham tDCS, active tDCS significantly improved self-evaluation based on body shape (p &lt; 0.05) and significantly decreased the need of excessive control over calorie intake (p &lt; 0.05) in the 4-week follow-up. However, the results do not survive multiple comparison correction. In both sham and active groups, the BMI values improved, albeit not significantly. Conclusion: We did not observe a significant effect of tDCS over the left DLPFC on complex psychopathology and weight recovery in patients with AN. tDCS reduced the need to follow specific dietary rules and improved body image evaluation in patients with AN. Tests with a larger sample and different positions of electrodes are needed.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30215 - Psychiatry

Project

<a href="/en/project/NV17-28905A" target="_blank" >NV17-28905A: The Role of Gut Microbiome and Autoimmune Mechanisms in Patients with Anorexia Nervosa</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Psychiatry

ISSN

1664-0640

e-ISSN

—

Volume of the periodical

12

Issue of the periodical within the volume

717255

Country of publishing house

CH - SWITZERLAND

Number of pages

11

Pages from-to

1-11

UT code for WoS article

000710734300001

EID of the result in the Scopus database

2-s2.0-85117527601