Socioeconomic deprivation in early life and symptoms of depression and anxiety in young adulthood: mediating role of hippocampal connectivity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F22%3A43920518" target="_blank" >RIV/00023752:_____/22:43920518 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/20:00124448 RIV/00216224:14740/22:00125564 RIV/00216208:11120/22:43920765 RIV/00216208:11130/22:10418890
Result on the web
<a href="https://www.cambridge.org/core/journals/psychological-medicine/article/socioeconomic-deprivation-in-early-life-and-symptoms-of-depression-and-anxiety-in-young-adulthood-mediating-role-of-hippocampal-connectivity/389D84B5689593935017EA38FA905E44" target="_blank" >https://www.cambridge.org/core/journals/psychological-medicine/article/socioeconomic-deprivation-in-early-life-and-symptoms-of-depression-and-anxiety-in-young-adulthood-mediating-role-of-hippocampal-connectivity/389D84B5689593935017EA38FA905E44</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1017/S0033291720004754" target="_blank" >10.1017/S0033291720004754</a>
Alternative languages
Result language
angličtina
Original language name
Socioeconomic deprivation in early life and symptoms of depression and anxiety in young adulthood: mediating role of hippocampal connectivity
Original language description
Background Experience of early-life socioeconomic deprivation (ELSD) may increase the risk of mental disorders in young adulthood. This association may be mediated by structural and functional alterations of the hippocampus. Methods We conducted a prospective cohort study on 122 participants of the European Longitudinal Study of Pregnancy and Childhood. Information about ELSD was collected via questionnaire from mothers during the first 18 months of participants' lives. At age 23-24, participants underwent examination by structural magnetic resonance imaging, resting-state functional connectivity and assessment of depressive symptoms (Mood and Feelings Questionnaire) and anxiety (Spielberger State-Trait Anxiety Inventory). The association of ELSD with brain outcomes in young adulthood was assessed with correlations, linear regression (adjusting for sex, socioeconomic position and mother's mental health) and moderated mediation analysis. Results Higher ELSD was associated with greater depressive symptoms (B = 0.22; p = 0.001), trait anxiety (B = 0.07; p = 0.02) and lower global connectivity of the right hippocampus (B =-0.01; p = 0.02). These associations persisted when adjusted for covariates. In women, lower global connectivity of the right hippocampus was associated with stronger trait anxiety (B =-4.14; p = 0.01). Global connectivity of the right hippocampus as well as connectivity between the right hippocampus and the left middle temporal gyrus mediated the association between ELSD and trait anxiety in women. Higher ELSD correlated with a lower volume of the right hippocampus in men, but the volume of the right hippocampus was not related to mental health. Conclusions Early preventive strategies targeted at children from socioeconomically deprived families may yield long-lasting benefits for the mental health of the population.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30215 - Psychiatry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Psychological Medicine
ISSN
0033-2917
e-ISSN
—
Volume of the periodical
52
Issue of the periodical within the volume
13
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
2671-2680
UT code for WoS article
000880310400031
EID of the result in the Scopus database
2-s2.0-85098200562