Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F22%3A43920912" target="_blank" >RIV/00023752:_____/22:43920912 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22330/22:43925212 RIV/60461373:22810/22:43925212

Result on the web

<a href="https://www.nature.com/articles/s41398-022-02039-0" target="_blank" >https://www.nature.com/articles/s41398-022-02039-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41398-022-02039-0" target="_blank" >10.1038/s41398-022-02039-0</a>

Result language

angličtina

Original language name

Microdosing with psilocybin mushrooms: a double-blind placebo-controlled study

Original language description

The use of low sub-perceptual doses of psychedelics (&quot;microdosing&quot;) has gained popularity in recent years. Although anecdotal reports claim multiple benefits associated with this practice, the lack of placebo-controlled studies severely limits our knowledge of microdosing and its effects. Moreover, research conducted in standard laboratory settings could fail to capture the motivation of individuals engaged or planning to engage in microdosing protocols, thus underestimating the likelihood of positive effects on creativity and cognitive function. We recruited 34 individuals starting to microdose with psilocybin mushrooms (Psilocybe cubensis), one of the materials most frequently used for this purpose. Following a double-blind placebo-controlled experimental design, we investigated the acute and short-term effects of 0.5 g of dried mushrooms on subjective experience, behavior, creativity (divergent and convergent thinking), perception, cognition, and brain activity. The reported acute effects were significantly more intense for the active dose compared to the placebo, but only for participants who correctly identified their experimental condition. These changes were accompanied by reduced EEG power in the theta band, together with preserved levels of Lempel-Ziv broadband signal complexity. For all other measurements there was no effect of microdosing except for few small changes towards cognitive impairment. According to our findings, low doses of psilocybin mushrooms can result in noticeable subjective effects and altered EEG rhythms, but without evidence to support enhanced well-being, creativity and cognitive function. We conclude that expectation underlies at least some of the anecdotal benefits attributed to microdosing with psilocybin mushrooms.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30215 - Psychiatry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Translational Psychiatry

ISSN

2158-3188

e-ISSN

2158-3188

Volume of the periodical

12

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

"Article Number: 307"

UT code for WoS article

000836626300001

EID of the result in the Scopus database

2-s2.0-85135215728