Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F23%3A43921053" target="_blank" >RIV/00023752:_____/23:43921053 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/23:00084143
Result on the web
<a href="https://www.pnas.org/doi/epdf/10.1073/pnas.2213880120" target="_blank" >https://www.pnas.org/doi/epdf/10.1073/pnas.2213880120</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1073/pnas.2213880120" target="_blank" >10.1073/pnas.2213880120</a>
Alternative languages
Result language
angličtina
Original language name
Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium
Original language description
Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, with MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macrostructural asymmetry may reflect differences at the molecular, cytoarchitectonic, or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30215 - Psychiatry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424
e-ISSN
1091-6490
Volume of the periodical
120
Issue of the periodical within the volume
14
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
"e2213880120"
UT code for WoS article
001038289700003
EID of the result in the Scopus database
2-s2.0-85151167995