Molecular Biomarkers of Neuronal Injury in Epilepsy Shared with Neurodegenerative Diseases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F23%3A43921063" target="_blank" >RIV/00023752:_____/23:43921063 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/23:00133507 RIV/00216208:11120/23:43925239 RIV/00159816:_____/23:00078775
Result on the web
<a href="https://link.springer.com/article/10.1007/s13311-023-01355-7" target="_blank" >https://link.springer.com/article/10.1007/s13311-023-01355-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13311-023-01355-7" target="_blank" >10.1007/s13311-023-01355-7</a>
Alternative languages
Result language
angličtina
Original language name
Molecular Biomarkers of Neuronal Injury in Epilepsy Shared with Neurodegenerative Diseases
Original language description
In neurodegenerative diseases, changes in neuronal proteins in the cerebrospinal fluid and blood are viewed as potential biomarkers of the primary pathology in the central nervous system (CNS). Recent reports suggest, however, that level of neuronal proteins in fluids also alters in several types of epilepsy in various age groups, including children. With increasing evidence supporting clinical and sub-clinical seizures in Alzheimer's disease, Lewy body dementia, Parkinson's disease, and in other less common neurodegenerative conditions, these findings call into question the specificity of neuronal protein response to neurodegenerative process and urge analysis of the effects of concomitant epilepsy and other comorbidities. In this article, we revisit the evidence for alterations in neuronal proteins in the blood and cerebrospinal fluid associated with epilepsy with and without neurodegenerative diseases. We discuss shared and distinctive characteristics of changes in neuronal markers, review their neurobiological mechanisms, and consider the emerging opportunities and challenges for their future research and diagnostic use.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neurotherapeutics
ISSN
1933-7213
e-ISSN
1878-7479
Volume of the periodical
20
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
767-778
UT code for WoS article
000945760600001
EID of the result in the Scopus database
2-s2.0-85149971500