Mega-analysis of association between obesity and cortical morphology in bipolar disorders: ENIGMA study in 2832 participants
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F23%3A43921083" target="_blank" >RIV/00023752:_____/23:43921083 - isvavai.cz</a>
Result on the web
<a href="https://www.cambridge.org/core/journals/psychological-medicine/article/megaanalysis-of-association-between-obesity-and-cortical-morphology-in-bipolar-disorders-enigma-study-in-2832-participants/E6B009D00AE42FFC90BA5E5A1A8B9406" target="_blank" >https://www.cambridge.org/core/journals/psychological-medicine/article/megaanalysis-of-association-between-obesity-and-cortical-morphology-in-bipolar-disorders-enigma-study-in-2832-participants/E6B009D00AE42FFC90BA5E5A1A8B9406</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1017/S0033291723000223" target="_blank" >10.1017/S0033291723000223</a>
Alternative languages
Result language
angličtina
Original language name
Mega-analysis of association between obesity and cortical morphology in bipolar disorders: ENIGMA study in 2832 participants
Original language description
Background:Obesity is highly prevalent and disabling, especially in individuals with severe mental illness including bipolar disorders (BD). The brain is a target organ for both obesity and BD. Yet, we do not understand how cortical brain alterations in BD and obesity interact. Methods:We obtained body mass index (BMI) and MRI-derived regional cortical thickness, surface area from 1231 BD and 1601 control individuals from 13 countries within the ENIGMA-BD Working Group. We jointly modeled the statistical effects of BD and BMI on brain structure using mixed effects and tested for interaction and mediation. We also investigated the impact of medications on the BMI-related associations. Results:BMI and BD additively impacted the structure of many of the same brain regions. Both BMI and BD were negatively associated with cortical thickness, but not surface area. In most regions the number of jointly used psychiatric medication classes remained associated with lower cortical thickness when controlling for BMI. In a single region, fusiform gyrus, about a third of the negative association between number of jointly used psychiatric medications and cortical thickness was mediated by association between the number of medications and higher BMI. Conclusions:We confirmed consistent associations between higher BMI and lower cortical thickness, but not surface area, across the cerebral mantle, in regions which were also associated with BD. Higher BMI in people with BD indicated more pronounced brain alterations. BMI is important for understanding the neuroanatomical changes in BD and the effects of psychiatric medications on the brain.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30215 - Psychiatry
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Psychological Medicine
ISSN
0033-2917
e-ISSN
1469-8978
Volume of the periodical
53
Issue of the periodical within the volume
14
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
6743-6753
UT code for WoS article
000948003300001
EID of the result in the Scopus database
2-s2.0-85174627053