Weight and metabolic changes in early psychosis-association with daily quantification of medication exposure during the first hospitalization

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F23%3A43921106" target="_blank" >RIV/00023752:_____/23:43921106 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/23:43925927

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/10.1111/acps.13594" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/acps.13594</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/acps.13594" target="_blank" >10.1111/acps.13594</a>

Result language

angličtina

Original language name

Weight and metabolic changes in early psychosis-association with daily quantification of medication exposure during the first hospitalization

Original language description

Background: The most common causes of death in schizophrenia are cardiovascular disorders, which are closely related to metabolic syndrome/obesity. To better understand the development of metabolic alterations early in the course of illness, we quantified daily medication exposure in the first days of the first hospitalization for psychosis and related it to changes in weight and metabolic markers. Study Design: We recruited participants with first episode psychosis (FEP, N = 173) during their first psychiatric hospitalization and compared them to controls (N = 204). We prospectively collected weight, body mass index, metabolic markers, and exact daily medication exposure at admission and during hospitalization. Study Results: Individuals with FEP gained on average 0.97 ± 2.26 BMI points or 3.46 ± 7.81 kg of weight after an average of 44.6 days of their first inpatient treatment. Greater antipsychotic exposure was associated with greater BMI increase, but only in people with normal/low baseline BMI. Additional predictors of weight gain included type of medication and duration of treatment. Medication exposure was not directly related to metabolic markers, but higher BMI was associated with higher TGC, TSH, and lower HDL. Following inpatient treatment, participants with FEP had significantly higher BMI, TGC, prolactin, and lower fT4, HDL than controls. Conclusion: During their first admission, people with FEP, especially those with normal/low baseline BMI, showed a rapid and clinically significant weight increase, which was associated with exposure to antipsychotics, and with metabolic changes consistent with metabolic syndrome. These findings emphasize weight monitoring in FEP and suggest a greater need for caution when prescribing metabolically problematic antipsychotics to people with lower BMI.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30215 - Psychiatry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Psychiatrica Scandinavica

ISSN

0001-690X

e-ISSN

1600-0447

Volume of the periodical

148

Issue of the periodical within the volume

3

Country of publishing house

DK - DENMARK

Number of pages

12

Pages from-to

265-276

UT code for WoS article

001041235500001

EID of the result in the Scopus database

2-s2.0-85166638901