Methadone administered to rat dams during pregnancy and lactation affects the circadian rhythms of their pups
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F23%3A43921116" target="_blank" >RIV/00023752:_____/23:43921116 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/23:10476712
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/jnr.25236" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/jnr.25236</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jnr.25236" target="_blank" >10.1002/jnr.25236</a>
Alternative languages
Result language
angličtina
Original language name
Methadone administered to rat dams during pregnancy and lactation affects the circadian rhythms of their pups
Original language description
The circadian clock is one of the most important homeostatic systems regulating the majority of physiological functions. Its proper development contributes significantly to the maintenance of health in adulthood. Methadone is recommended for the treatment of opioid use disorders during pregnancy, increasing the number of children prenatally exposed to long-acting opioids. Although early-life opioid exposure has been studied for a number of behavioral and physiological changes observed later in life, information on the relationship between the effects of methadone exposure and circadian system development is lacking. Using a rat model, we investigated the effects of prenatal and early postnatal methadone administration on the maturation of the circadian clockwork in the suprachiasmatic nucleus (SCN) and liver, the rhythm of aralkylamine N-acetyltransferase (AA-NAT) activity in the pineal gland, and gene expression in the livers of 20-day-old rats. Our data show that repeated administration of methadone to pregnant and lactating mothers has significant effect on rhythmic gene expression in the SCN and livers and on the rhythm of AA-NAT in the offspring. Similar to previous studies with morphine, the rhythm amplitudes of the clock genes in the SCN and liver were unchanged or enhanced. However, six of seven specific genes in the liver showed significant downregulation of their expression, compared to the controls in at least one experimental group. Importantly, the amplitude of the AA-NAT rhythm was significantly reduced in all methadone-treated groups. As there is a strong correlation with melatonin levels, this result could be of importance for clinical practice.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neuroscience Research
ISSN
0360-4012
e-ISSN
1097-4547
Volume of the periodical
101
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
20
Pages from-to
1737-1756
UT code for WoS article
001044175200001
EID of the result in the Scopus database
2-s2.0-85167329054