Guardians of Rest? Investigating the gut microbiota in central hypersomnolence disorders
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F23%3A43921212" target="_blank" >RIV/00023752:_____/23:43921212 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/24:00580472
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1389945723004422?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1389945723004422?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.sleep.2023.11.024" target="_blank" >10.1016/j.sleep.2023.11.024</a>
Alternative languages
Result language
angličtina
Original language name
Guardians of Rest? Investigating the gut microbiota in central hypersomnolence disorders
Original language description
In recent years, there has been an increased interest in elucidating the influence of the gut microbiota on sleep physiology. The gut microbiota affects the central nervous system by modulating neuronal pathways through the neuroendocrine and immune system, the hypothalamus-pituitary-adrenal axis, and various metabolic pathways. The gut microbiota can also influence circadian rhythms. In this study, we observed the gut microbiota composition of patients suffering from narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. We did not observe any changes in the alpha diversity of the gut microbiota among patient groups and healthy controls. We observed changes in beta diversity in accordance with Jaccard dissimilarities between the control group and groups of patients suffering from narcolepsy type 1 and idiopathic hypersomnia. Our results indicate that both these patient groups differ from controls relative to the presence of rare bacterial taxa. However, after adjustment for various confounding factors such as BMI, age, and gender, there were no statistical differences among the groups. This indicates that the divergence in beta diversity in the narcolepsy type 1 and idiopathic hypersomnia groups did not arise due to sleep disturbances. This study implies that using metabolomics and proteomics approaches to study the role of microbiota in sleep disorders might prove beneficial.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
<a href="/en/project/NU20-04-00088" target="_blank" >NU20-04-00088: Gut microbiome and autoimmune mechanisms in patients with central hypersomnia</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Sleep Medicine
ISSN
1389-9457
e-ISSN
1878-5506
Volume of the periodical
113
Issue of the periodical within the volume
January
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
95-102
UT code for WoS article
001124371000001
EID of the result in the Scopus database
2-s2.0-85177816120