Cellular and molecular mechanisms of action of ovarian steroid hormones. I: Regulation of central nervous system function

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F23%3A43921388" target="_blank" >RIV/00023752:_____/23:43921388 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11240/24:10492124
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0149763424004068?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0149763424004068?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.neubiorev.2024.105937" target="_blank" >10.1016/j.neubiorev.2024.105937</a>

Result language
angličtina
Original language name
Cellular and molecular mechanisms of action of ovarian steroid hormones. I: Regulation of central nervous system function
Original language description
The conventional way steroid hormones work through receptors inside cells is widely acknowledged. There are unanswered questions about what happens to the hormone in the end and why there isn't always a strong connection between how much tissue takes up and its biological effects through receptor binding. Steroid hormones can also have non-traditional effects that happen quickly but don't involve entering the cell. Several possible mechanisms for these non-traditional actions include (a) changes in membrane fluidity, (b) steroid hormones acting on receptors on the outer surface of cells, (c) steroid hormones regulating GABAA receptors on cell membranes, and (d) activation of steroid receptors by factors like EGF, IGF-1, and dopamine. Data also suggests that steroid hormones may be inserted into DNA through receptors, acting as transcription factors. These proposed new mechanisms of action should not be seen as challenging the conventional mechanism. Instead, they contribute to a more comprehensive understanding of how hormones work, allowing for rapid, short-term, and prolonged effects to meet the body's physiological needs.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30103 - Neurosciences (including psychophysiology)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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