Effects of cabergoline and dimethylcabergoline on the sexual behavior of male rats. Psychopharmacology

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F24%3A43921189" target="_blank" >RIV/00023752:_____/24:43921189 - isvavai.cz</a>

Result on the web

<a href="https://link.springer.com/article/10.1007/s00213-023-06501-9" target="_blank" >https://link.springer.com/article/10.1007/s00213-023-06501-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00213-023-06501-9" target="_blank" >10.1007/s00213-023-06501-9</a>

Result language

angličtina

Original language name

Effects of cabergoline and dimethylcabergoline on the sexual behavior of male rats. Psychopharmacology

Original language description

Rationale Cabergoline (CAB) is an ergot derivative typically prescribed for the treatment of hyperprolactinemia. It suppressesthe release of prolactin through agonist actions on dopamine (DA) D2 receptors; however, it possesses binding afnity forother DA and 5-HT receptors. Side efects that exacerbate valvular heart disease can occur with high doses.Objective The present study examined the acute, subchronic, and chronic dose–response efects of CAB and a derivativedimethylcabergoline (DMC) which acts as an antagonist instead of agonist at 5-HT 2B receptors, on appetitive and consummatory sexual behaviors of male rats.Methods CAB (0, 0.03, 0.15, or 0.3 mg/kg/ml) was administered daily to sexually experienced male rats (N=10/dose) byoral gavage for a total of 68 days. Sexual behavior was tested every 4 days during this period for a total of 16 trials. On the17th trial, rats were administered their dose of CAB, and 4 h after were overdosed with sodium pentobarbital, perfused intracardially, and their brains processed for Fos immunohistochemistry. DMC (0, 0.03, 0.15, 0.3 mg/kg/ml) was administereddaily to sexually experienced male rats (N=10/dose) by oral gavage for a total of 36 days. Sexual behavior was tested every4 days for a total of 9 trials.Results CAB increased anticipatory level changes, intromissions, and ejaculations signifcantly across all timepoints, withthe medium and high doses being most potent. The medium and high doses also increased Fos protein signifcantly withinthe medial preoptic area, whereas in the nucleus accumbens shell, the low and medium doses decreased Fos protein but thehigh dose increased it signifcantly from control. Similar to CAB, the medium and high doses of DMC increased the numberof ejaculations signifcantly. Rats in all drug dose groups appeared healthy for the duration of the experiments.Conclusions Both CAB and DMC facilitate ejaculations, and CAB further facilitates measures of anticipatory sexual motivation and intromissions. These data suggest that both could be used as treatments for sexual arousal disorders and ejaculation/orgasm disorders with little or no untoward side efects at low doses.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30105 - Physiology (including cytology)

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Psychopharmacology

ISSN

0033-3158

e-ISSN

1432-2072

Volume of the periodical

241

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

717-726

UT code for WoS article

001102302300002

EID of the result in the Scopus database

2-s2.0-85176813368