Time is the enemy: Negative symptoms are related to even slight differences in the duration of untreated psychosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F24%3A43921261" target="_blank" >RIV/00023752:_____/24:43921261 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/24:43926557
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0010440X24000014?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0010440X24000014?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.comppsych.2024.152450" target="_blank" >10.1016/j.comppsych.2024.152450</a>
Alternative languages
Result language
angličtina
Original language name
Time is the enemy: Negative symptoms are related to even slight differences in the duration of untreated psychosis
Original language description
Background: Negative symptoms (NS) represent a detrimental symptomatic domain in schizophrenia affecting social and occupational outcomes. Aims: We aimed to identify factors from the baseline visit (V1) - with a mean illness duration of 0.47 years (SD = 0.45) - that predict the magnitude of NS at the follow-up visit (V3), occurring 4.4 years later (mean +/0.45). Method: Using longitudinal data from 77 first -episode schizophrenia spectrum patients, we analysed eight predictors of NS severity at V3: (1) the age at disease onset, (2) age at V1, (3) sex, (4) diagnosis, (5) NS severity at V1, (6) the dose of antipsychotic medication at V3, (7) hospitalisation days before V1 and; (8) the duration of untreated psychosis /DUP/). Secondly, using a multiple linear regression model, we studied the longitudinal relationship between such identified predictors and NS severity at V3 using a multiple linear regression model. Results: DUP (Pearson's r = 0.37, p = 0.001) and NS severity at V1 (Pearson's r = 0.49, p < 0.001) survived correction for multiple comparisons. The logarithmic -like relationship between DUP and NS was responsible for the initial stunning incremental contribution of DUP to the severity of NS. For DUP < 6 months, with the sharpest DUP/NS correlation, prolonging DUP by five days resulted in a measurable one -point increase in the 6 -item negative symptoms PANSS domain assessed 4.9 (+/- 0.6) years after the illness onset. Prolongation of DUP to 14.7 days doubled this NS gain, whereas 39 days longer DUP tripled NS increase. Conclusion: The results suggest the petrification of NS during the early stages of the schizophrenia spectrum and a crucial dependence of this symptom domain on DUP. These findings are clinically significant and highlight the need for primary preventive actions.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30215 - Psychiatry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Comprehensive Psychiatry
ISSN
0010-440X
e-ISSN
1532-8384
Volume of the periodical
130
Issue of the periodical within the volume
April
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
152450
UT code for WoS article
001169442000001
EID of the result in the Scopus database
2-s2.0-85183572831