Cholinergic modulation supports dynamic switching of resting state networks through selective DMN suppression
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F24%3A43921285" target="_blank" >RIV/00023752:_____/24:43921285 - isvavai.cz</a>
Alternative codes found
RIV/67985807:_____/24:00586902 RIV/00023001:_____/24:00084907
Result on the web
<a href="https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012099" target="_blank" >https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012099</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pcbi.1012099" target="_blank" >10.1371/journal.pcbi.1012099</a>
Alternative languages
Result language
angličtina
Original language name
Cholinergic modulation supports dynamic switching of resting state networks through selective DMN suppression
Original language description
Brain activity during the resting state is widely used to examine brain organization, cognition and alterations in disease states. While it is known that neuromodulation and the state of alertness impact resting-state activity, neural mechanisms behind such modulation of resting-state activity are unknown. In this work, we used a computational model to demonstrate that change in excitability and recurrent connections, due to cholinergic modulation, impacts resting-state activity. The results of such modulation in the model match closely with experimental work on direct cholinergic modulation of Default Mode Network (DMN) in rodents. We further extended our study to the human connectome derived from diffusion-weighted MRI. In human resting-state simulations, an increase in cholinergic input resulted in a brain-wide reduction of functional connectivity. Furthermore, selective cholinergic modulation of DMN closely captured experimentally observed transitions between the baseline resting state and states with suppressed DMN fluctuations associated with attention to external tasks. Our study thus provides insight into potential neural mechanisms for the effects of cholinergic neuromodulation on resting-state activity and its dynamics.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/GA21-32608S" target="_blank" >GA21-32608S: Characterizing state repertoire and dynamics of spontaneous brain activity by neuroimaging methods</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS Computational Biology
ISSN
1553-734X
e-ISSN
1553-7358
Volume of the periodical
20
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
26
Pages from-to
"Article Number e1012099"
UT code for WoS article
001241870900005
EID of the result in the Scopus database
2-s2.0-85195496067