Acute ethanol disrupts conditioned inhibition in the male rat
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F24%3A43921301" target="_blank" >RIV/00023752:_____/24:43921301 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11240/24:10492174
Result on the web
<a href="https://link.springer.com/article/10.1007/s00213-024-06618-5" target="_blank" >https://link.springer.com/article/10.1007/s00213-024-06618-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00213-024-06618-5" target="_blank" >10.1007/s00213-024-06618-5</a>
Alternative languages
Result language
angličtina
Original language name
Acute ethanol disrupts conditioned inhibition in the male rat
Original language description
RationaleAlcohol can disrupt conditioned sexual inhibition (CSI) established by first-order conditioning in male rats. CSI can also be induced using second-order conditioning, during which male rats are trained to associate a neutral odor with a nonreceptive female. As a result, when given access to two receptive females (one scented and one unscented) during a copulatory preference test, they display CSI toward the scented female.ObjectiveThe present study examined the effect of low-to-moderate doses of alcohol on CSI and brain activation following exposure to alcohol and the olfactory cue alone.MethodsSexually-na & iuml;ve Long-Evans rats received alternate conditioning sessions with unscented receptive or scented (almond extract) non-receptive females. Following the conditioning phase, males were injected with saline, alcohol 0.5 g/kg or 1 g/kg, 45 min before a copulatory test with two receptive females, with one bearing the olfactory cue. Fos activation was later assessed, following exposure to alcohol and the olfactory cue alone, in several brain regions involved in the expression and regulation of male sexual behavior.ResultsWhile males in the saline group displayed sexual avoidance towards the scented female, those injected with alcohol before the copulatory test, regardless of the dose, copulated indiscriminately with both females. Subsequent exposure to alcohol and the olfactory cue alone induced different Fos expression between groups in several brain regions.ConclusionsLow to moderate doses of alcohol disrupt conditioned sexual inhibition in male rats and induce a differential pattern of neural activation, particularly in regions involved in the expression and regulation of sexual behavior.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Psychopharmacology
ISSN
0033-3158
e-ISSN
1432-2072
Volume of the periodical
241
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
2061-2071
UT code for WoS article
001236097300001
EID of the result in the Scopus database
2-s2.0-85195151060