Mood regulation in euthymic patients with a history of antidepressant-induced mania

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F24%3A43921330" target="_blank" >RIV/00023752:_____/24:43921330 - isvavai.cz</a>

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/10.1111/bdi.13504" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/bdi.13504</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/bdi.13504" target="_blank" >10.1111/bdi.13504</a>

Result language

angličtina

Original language name

Mood regulation in euthymic patients with a history of antidepressant-induced mania

Original language description

IntroductionThe use of antidepressants in bipolar disorder (BD) remains contentious, in part due to the risk of antidepressant-induced mania (AIM). However, there is no information on the architecture of mood regulation in patients who have experienced AIM. We compared the architecture of mood regulation in euthymic patients with and without a history of AIM.MethodsEighty-four euthymic participants were included. Participants rated their mood, anxiety and energy levels daily using an electronic (e-) visual analog scale, for a mean (SD) of 280.8(151.4) days. We analyzed their multivariate time series by computing each variable&apos;s auto-correlation, inter-variable cross-correlation, and composite multiscale entropy of mood, anxiety, and energy. Then, we compared the data features of participants with a history of AIM and those without AIM, using analysis of covariance, controlling for age, sex, and current treatment.ResultsBased on 18,103 daily observations, participants with AIM showed significantly stronger day-to-day auto-correlation and cross-correlation for mood, anxiety, and energy than those without AIM. The highest cross-correlation in participants with AIM was between mood and energy within the same day (median (IQR), 0.58 (0.27)). The strongest negative cross-correlation in participants with AIM was between mood and anxiety series within the same day (median (IQR), -0.52 (0.34)).ConclusionPatients with a history of AIM have a different underlying mood architecture compared to those without AIM. Their mood, anxiety and energy stay the same from day-to-day; and their anxiety is negatively correlated with their mood.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30215 - Psychiatry

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bipolar Disorders

ISSN

1398-5647

e-ISSN

1399-5618

Volume of the periodical

26

Issue of the periodical within the volume

8

Country of publishing house

DK - DENMARK

Number of pages

10

Pages from-to

810-819

UT code for WoS article

001320433600001

EID of the result in the Scopus database

2-s2.0-85205297931