Steroidomics in Men with Schizophrenia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F24%3A43921334" target="_blank" >RIV/00023752:_____/24:43921334 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/24:43927497 RIV/00023761:_____/24:N0000030
Result on the web
<a href="https://www.mdpi.com/1422-0067/25/16/8729" target="_blank" >https://www.mdpi.com/1422-0067/25/16/8729</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms25168729" target="_blank" >10.3390/ijms25168729</a>
Alternative languages
Result language
angličtina
Original language name
Steroidomics in Men with Schizophrenia
Original language description
Schizophrenia is associated with numerous abnormalities, including imbalances in all hormonal axes, among which steroids play a major role. Steroidomic studies therefore represent a promising tool for early diagnosis and appropriate treatment of schizophrenia. A total of 51 adult male schizophrenics aged 27 (22, 34) years (shown as median with quartiles) and 16 healthy controls (HCs) aged 28 (25, 32) years were enrolled into this study. Our results showed the effective differentiation of men with schizophrenia from controls based on steroidomic profiles. We also found an altered metabolic pathway from pregnenolone and its sulfate (PREG/S) to cortisol in schizophrenics with several metabolic bottlenecks such as lower PREG levels due to increased PREG sulfation and/or suppressed PREGS desulfation and attenuated conversion of 17-hydroxy-PREG to 17-hydroxy-progesterone, as well as the results suggestive of suppressed CYP11B1 activity. In contrast, steroid molar ratios suggested two counterregulatory steps involving increased conversion of PREG/S to 17-hydroxy-PREG/S and decreased conversion of cortisol to cortisone, which may maintain unchanged basal cortisol levels but may not ensure a sufficient cortisol response to stress. Our data also indicated a trend to higher 7 alpha-, 7 beta-, and 16 alpha-hydroxylation that may counteract the autoimmune complications and proinflammatory processes accompanying schizophrenia. Finally, a possible suppression of HSD17B3 activity was suggested, resulting in decreased circulating testosterone levels with increased androstenedione levels.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/NU20-04-00389" target="_blank" >NU20-04-00389: Role of neuroactive steroids in mechnanism of action of clozapine</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1661-6596
e-ISSN
1422-0067
Volume of the periodical
25
Issue of the periodical within the volume
16
Country of publishing house
CH - SWITZERLAND
Number of pages
38
Pages from-to
"Article number 8729"
UT code for WoS article
001305348200001
EID of the result in the Scopus database
2-s2.0-85202649798