The time has come for revising the rules of clozapine blood monitoring in Europe. A joint expert statement from the European Clozapine Task Force

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F25%3A43921493" target="_blank" >RIV/00023752:_____/25:43921493 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/25:43927866

Result on the web

<a href="https://doi.org/10.1192/j.eurpsy.2024.1816" target="_blank" >https://doi.org/10.1192/j.eurpsy.2024.1816</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1192/j.eurpsy.2024.1816" target="_blank" >10.1192/j.eurpsy.2024.1816</a>

Result language

angličtina

Original language name

The time has come for revising the rules of clozapine blood monitoring in Europe. A joint expert statement from the European Clozapine Task Force

Original language description

The European Clozapine Task Force is a group of psychiatrists and pharmacologists practicing in 18 countries under European Medicines Agency (EMA) regulation, who are deeply concerned about the underuse of clozapine in European countries. Although clozapine is the most effective antipsychotic for people with treatment-resistant schizophrenia, a large proportion of them do not have access to this treatment. Concerns about clozapine-induced agranulocytosis and stringent blood monitoring rules are major barriers to clozapine prescribing and use. There is a growing body of evidence that the incidence of clozapine-induced agranulocytosis is very low after the first year of treatment. Maintaining lifelong monthly blood monitoring after this period contributes to unjustified discontinuation of clozapine. We leverage recent and replicated evidence on the long-term safety of clozapine to call for the revision and updating of the EMA&apos;s blood monitoring rules, thus aiming to overcome this major barrier to clozapine prescribing and use. We believe the time has come for relaxing the rules without increasing the risks for people using clozapine in Europe.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30215 - Psychiatry

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Psychiatry

ISSN

0924-9338

e-ISSN

1778-3585

Volume of the periodical

68

Issue of the periodical within the volume

1

Country of publishing house

FR - FRANCE

Number of pages

5

Pages from-to

"e17"

UT code for WoS article

001406118900001

EID of the result in the Scopus database

2-s2.0-85215574552