Exploring 5-MeO-DMT as a pharmacological model for deconstructed consciousness
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F25%3A43921502" target="_blank" >RIV/00023752:_____/25:43921502 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/25:43928388 RIV/60461373:22330/25:43932751 RIV/60461373:22810/25:43932751
Result on the web
<a href="https://doi.org/10.1093/nc/niaf007" target="_blank" >https://doi.org/10.1093/nc/niaf007</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/nc/niaf007" target="_blank" >10.1093/nc/niaf007</a>
Alternative languages
Result language
angličtina
Original language name
Exploring 5-MeO-DMT as a pharmacological model for deconstructed consciousness
Original language description
5-MeO-DMT is a short-acting psychedelic that is anecdotally reported to induce a radical disruption of the self and a paradoxical quality of aroused, waking awareness that is nevertheless devoid of any specific perceptual contents. Here, we conducted an exploratory observational study of the phenomenological and neuronal effects of this compound. We collected micro-phenomenological interviews, psychometric questionnaires, and electroencephalography (EEG) in naturalistic ceremonial settings where 5-MeO-DMT was ingested. Results revealed that the 5-MeO-DMT experience followed a dynamic progression that—only in the most extreme cases—manifested as a complete absence of self-experience and other phenomenal content with preserved awareness. Furthermore, visual imagery, bodily self-disruption, narrative self-disruption, and reduced phenomenal distinctions occurred in a variable fashion. EEG analyses revealed the 5-MeO-DMT experience was characterised by (global) alpha and (posterior) beta power reductions, implying a mode of brain functioning where top-down models are inhibited. Our preliminary phenomenological findings confirm the potential utility of 5-MeO-DMT as a pharmacological model for deconstructed consciousness while noting the limitations of employing retrospective questionnaires for this purpose. Considering the exploratory nature of this study and its limitations inherent to its naturalistic nature, further research employing real-time experience sampling and phenomenologically trained participants in controlled environments could expand our findings to meaningfully inform the potential of this tool for the scientific study of consciousness.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neuroscience of Consciousness
ISSN
2057-2107
e-ISSN
2057-2107
Volume of the periodical
2025
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
"niaf007"
UT code for WoS article
001472609300001
EID of the result in the Scopus database
2-s2.0-105003187361