Current Status, Opportunities, Applications, and Challenges of RNA Interference-Based Cancer Therapeutics
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F25%3A43921629" target="_blank" >RIV/00023752:_____/25:43921629 - isvavai.cz</a>
Result on the web
<a href="https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202504048" target="_blank" >https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202504048</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/slct.202504048" target="_blank" >10.1002/slct.202504048</a>
Alternative languages
Result language
angličtina
Original language name
Current Status, Opportunities, Applications, and Challenges of RNA Interference-Based Cancer Therapeutics
Original language description
Cancer is one of the leading causes of death globally, where the development of effective therapies is critical. Traditional cancer treatment methods, such as chemotherapy and radiation, often lead to several side effects in patients due to their systemic toxicity and the emergence of drug resistance. Thus, there is a quest for an alternative approach for less/nontoxic cancer treatment modalities. One of the most fascinating and practical biological discoveries in recent years is the phenomenon of RNA interference (RNAi), which serves as a regulator of gene expression. Across the spectrum of organisms, suppressing gene expression can be swiftly and effectively accomplished using double-stranded RNA-mediated interference. Hence, RNAi is proposed as a potential cancer treatment alternative by enabling targeted silencing of genes, which can disrupt the expression of oncogenes and restore the function of tumor suppressor genes. However, the successful implementation of RNAi requires efficient delivery systems that can play a vital role in overcoming the barriers associated with stability and cellular uptake. Thus, this review aims to discuss the abilities of RNA interference in cancer therapy, examining its challenges and its future perspectives.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ChemistrySelect
ISSN
2365-6549
e-ISSN
2365-6549
Volume of the periodical
10
Issue of the periodical within the volume
46
Country of publishing house
DE - GERMANY
Number of pages
24
Pages from-to
"e04048"
UT code for WoS article
001630395300001
EID of the result in the Scopus database
2-s2.0-105023870020