The Application of Gamma-Range Auditory Steady-State Responses in Animal Models: A Semi-Structured Literature Review
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F25%3A43921632" target="_blank" >RIV/00023752:_____/25:43921632 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/25:43929138
Result on the web
<a href="https://www.mdpi.com/2076-3425/15/11/1159" target="_blank" >https://www.mdpi.com/2076-3425/15/11/1159</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/brainsci15111159" target="_blank" >10.3390/brainsci15111159</a>
Alternative languages
Result language
angličtina
Original language name
The Application of Gamma-Range Auditory Steady-State Responses in Animal Models: A Semi-Structured Literature Review
Original language description
Background: Gamma-range auditory steady-state responses (ASSRs) are emerging as promising translational biomarkers of neural network function. While extensively studied in human neuropsychiatric and neurodevelopmental research, their application in animal models has expanded in recent years, providing mechanistic insights into disease-related neural dynamics. However, methodological approaches vary widely, findings remain fragmented, and outcomes are not easily generalized. Methods: A literature search was conducted in March 2025 across PubMed and Scopus to identify studies investigating gamma-range ASSRs (30-100 Hz) in animal models with relevance to psychiatric and developmental conditions. Results: Most studies employed rodents, with a smaller number involving non-human primates, and used pharmacological, genetic, lesion-based, or developmental manipulations relevant to schizophrenia, autism spectrum disorder, and related conditions. ASSRs were highly sensitive to NMDA receptor antagonism, state- and trait-related factors, and exhibited region- and layer-specific generation patterns centered on the auditory cortex. Less common paradigms, such as chirps and gap-in-noise, also demonstrated translational potential. Conclusions: Animal research confirms that gamma-range ASSRs provide a sensitive, cross-species readout of circuit dysfunctions observed in psychiatric and neurodevelopmental disorders. To maximize their translational utility, future work should prioritize methodological harmonization, systematic inclusion of sex and behavioral state factors, and replication across laboratories. Strengthening these aspects will enhance the value of ASSRs as biomarkers for early detection, patient stratification, and treatment monitoring in clinical psychiatry.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/EH22_008%2F0004643" target="_blank" >EH22_008/0004643: Brain dynamics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Brain Sciences
ISSN
2076-3425
e-ISSN
2076-3425
Volume of the periodical
15
Issue of the periodical within the volume
11
Country of publishing house
CH - SWITZERLAND
Number of pages
15
Pages from-to
1159
UT code for WoS article
001624050100001
EID of the result in the Scopus database
2-s2.0-105023662326