Corollary discharge and efference copy mechanisms in schizophrenia and controls: The N1 and P2 evoked potential components differentially react to self-initiated tones in schizophrenia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F25%3A43921653" target="_blank" >RIV/00023752:_____/25:43921653 - isvavai.cz</a>
Result on the web
<a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0336046" target="_blank" >https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0336046</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0336046" target="_blank" >10.1371/journal.pone.0336046</a>
Alternative languages
Result language
angličtina
Original language name
Corollary discharge and efference copy mechanisms in schizophrenia and controls: The N1 and P2 evoked potential components differentially react to self-initiated tones in schizophrenia
Original language description
"Efference copy" and "corollary discharge" mechanisms may help to distinguish internal from external stimuli. Previous studies indicate that patients with schizophrenia show a lack of N1 evoked response potential component amplitude suppression to self-initiated auditory stimuli, suggesting a corollary discharge impairment. In our study, we examined N1 and P2 component amplitude suppression in 27 patients with schizophrenia and 30 healthy controls using an auditory button-press paradigm. In addition to symptom ratings we conducted neuropsychological assessments. Our findings replicated N1 amplitude suppression to self-generated tones in schizophrenia patients. We found no correlation between N1, P2, and lateralized readiness potential, suggesting that the readiness potential may not directly represent corollary discharge mechanisms. Cognition performance was reduced in schizophrenia patients and performance reduction correlated with negative symptoms. Cognition was not associated with evoked potential data. Regarding the P2 component, P2 suppression to self-generated tones was observed in patients as well as in controls. In conclusion, the N1 and the P2 component seem to be differentially involved in corollary discharge and efference copy mechanisms. Further investigation is needed to elucidate functional differences and sources of both components in this context.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10700 - Other natural sciences
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS One
ISSN
1932-6203
e-ISSN
1932-6203
Volume of the periodical
20
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
21
Pages from-to
"e0336046"
UT code for WoS article
001641400300036
EID of the result in the Scopus database
2-s2.0-105024741712