Reduced Levels of Circulating 7 alpha-Hydroxy-Dehydroepiandrosterone in Treated Adolescent Obese Patients

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023761%3A_____%2F14%3A%230000465" target="_blank" >RIV/00023761:_____/14:#0000465 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Reduced Levels of Circulating 7 alpha-Hydroxy-Dehydroepiandrosterone in Treated Adolescent Obese Patients
Original language description
Elevated levels of glucocorticoids lead to the development of obesity and metabolic syndrome. Local glucocorticoid levels are regulated through the enzyme 11 beta-hydroxysteroid dehydrogenase 1 (11 beta-HSD 1), an enzyme that regenerates active cortisolfrom inert cortisone. Increased expression of 11 beta-HSD 1 in adipose tissue promotes higher body mass index (BMI), insulin resistance, hypertension, and dyslipidemia. Human 11 beta-HSD 1 is also responsible for inter-conversion of 7-hydroxylate metabolites of dehydroepiandrosterone (7-OH-DHEA) to their 7-oxo-form. To better understanding the mechanism of the action, we focused on 7-OH- and 7-oxo-DHEA, and their circulating levels during the reductive treatment in adolescent obese patients.
Czech name
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Czech description
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Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30308 - Nutrition, Dietetics

Project
<a href="/en/project/NT13542" target="_blank" >NT13542: The importance of the enzyme 11beta-hydroxysteroid dehydrogenase type 1 in human obesity</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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