No Change in Serum Incretins Levels but Rise of Leptin Levels After Smoking Cessation: a Pilot Study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023761%3A_____%2F16%3AN0000035" target="_blank" >RIV/00023761:_____/16:N0000035 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/16:10329186 RIV/00064165:_____/16:10329186
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
No Change in Serum Incretins Levels but Rise of Leptin Levels After Smoking Cessation: a Pilot Study
Original language description
The mechanisms behind the changes of body weight after smoking cessation are only partially understood. To this end, we explored the possible effects of smoking cessation on incretin hormones, leptin and selected anthropometric, biochemical and other hormonal parameters. Twenty-two non-obese male adult smokers attending an ambulatory smoking cessation program in Prague, Czech Republic, were examined at the baseline. Thirteen patients (mean age 37.92 +/- 2.66 years, mean body mass index 25.56 +/- 0.69 kg/m(2)) successfully quit smoking and were examined three months after smoking cessation; relapsed smokers were not followed up. The patients underwent 2-h liquid meal test with Fresubin and repeated blood sampling for measurements of blood glucose, gastric inhibitory polypeptide (GIP), glucagon-like peptide 1 (GLP-1), amylin, insulin, leptin, peptide-YY (PYY) and pancreatic polypeptide (PP). Three months after smoking cessation, body weight increased (4.35 +/- 3.32 kg, p<0.001). Leptin levels increased significantly in all repeated samples, while levels of GIP, GLP-1, amylin, insulin, PYY and PP remained unchanged. In conclusions, smoking cessation increased leptin levels probably owing to weight gain while it did not influence incretin levels.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
—

Project
<a href="/en/project/NT12170" target="_blank" >NT12170: Genetic determination of the nicotine dependence and the efficaccy of the nicotine dependence treatment</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)