Associations between olfactory pathway gene methylation marks, obesity features and dietary intakes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023761%3A_____%2F19%3AN0000021" target="_blank" >RIV/00023761:_____/19:N0000021 - isvavai.cz</a>
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485100/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485100/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12263-019-0635-9" target="_blank" >10.1186/s12263-019-0635-9</a>
Alternative languages
Result language
angličtina
Original language name
Associations between olfactory pathway gene methylation marks, obesity features and dietary intakes
Original language description
Olfaction is an important sense influencing food preferences, appetite, and eating behaviors. This hypothesis-driven study aimed to assess associations between olfactory pathway gene methylation signatures, obesity features, and dietary intakes. A nutriepigenomic analysis was conducted in 474 adults from the Methyl Epigenome Network Association (MENA) project. Anthropometric measurements, clinical data, and serum metabolic profiles of the study population were obtained from structured databases of the MENA cohorts. Habitual dietary intake was assessed using a validated semiquantitative food frequency questionnaire. DNA methylation was measured in circulating white blood cells by microarray (Infinium Human Methylation 450K BeadChips). FDR values (p<0.0001) were used to select those CpGs that showed the best correlation with body mass index (BMI) and waist circumference (WC). Pathway analyses involving the characterization of genes involved in the olfactory transduction system were performed using KEGG and pathDIP reference databases. Overall, 15 CpG sites at olfactory pathway genes were associated with BMI (p<0.0001) and WC (p<0.0001) after adjustments for potential confounding factors. Together, methylation levels at the15 CpG sites accounted for 22% and 20% of the variability in BMI and WC (r(2)=0.219, p<0.001, and r(2)=0.204, p<0.001, respectively). These genes encompassed olfactory receptors (OR4D2, OR51A7, OR2T34, and OR2Y1) and several downstream signaling molecules (SLC8A1, ANO2, PDE2A, CALML3, GNG7, CALML6, PRKG1, and CAMK2D), which significantly regulated odor detection and signal transduction processes within the complete olfactory cascade, as revealed by pathway enrichment analyses (p=1.94x10(-10)). Moreover, OR4D2 and OR2Y1 gene methylation patterns strongly correlated with daily intakes of total energy (p<0.0001), carbohydrates (p<0.0001), protein (p<0.0001), and fat (p<0.0001). The results of this study suggest novel relationships between olfactory pathway gene methylation signatures, obesity indices, and dietary intakes.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30308 - Nutrition, Dietetics
Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
GENES AND NUTRITION
ISSN
1555-8932
e-ISSN
1865-3499
Volume of the periodical
14
Issue of the periodical within the volume
11
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
nestrankovano
UT code for WoS article
000465968300002
EID of the result in the Scopus database
2-s2.0-85065243457