11-Keto-testosterone and other androgens of adrenal origin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023761%3A_____%2F20%3AN0000032" target="_blank" >RIV/00023761:_____/20:N0000032 - isvavai.cz</a>
Result on the web
<a href="http://www.biomed.cas.cz/physiolres/pdf/2020/69_S187.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/2020/69_S187.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
11-Keto-testosterone and other androgens of adrenal origin
Original language description
The adrenal glands produce significant amounts of steroid hormones and their metabolites, with various levels of androgenic activities. Until recently, the androgenic potency of these adrenal-derived compounds were not well known, but some recent studies have shown that the production of 11-oxo-and 11 beta-hydroxy-derived testosterone and dihydrotestosterone evidently have high androgenic activity. This fact has clinical importance, for instance, in various types of congenital adrenal hyperplasia with androgenization or polycystic ovarian syndrome, and laboratory determinations of these substances could help to better evaluate the total androgen pressure in patients with these disorders. Another area of concern is the treatment of prostate cancer with androgen deprivation, which loses effectiveness after a certain time. The concurrent blocking of the secretion of adrenal C-19-steroids, whether using corticoids or adrenostatics, could increase the effectiveness of androgen-deprivation therapy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
1802-9973
Volume of the periodical
69
Issue of the periodical within the volume
Supplement 2
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
6
Pages from-to
"S-187"-"S-192"
UT code for WoS article
000581646000003
EID of the result in the Scopus database
2-s2.0-85094193394