Vitamin D and new insights into pathophysiology of type 2 diabetes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023761%3A_____%2F21%3AN0000034" target="_blank" >RIV/00023761:_____/21:N0000034 - isvavai.cz</a>
Result on the web
<a href="https://www.degruyter.com/document/doi/10.1515/hmbci-2020-0055/html" target="_blank" >https://www.degruyter.com/document/doi/10.1515/hmbci-2020-0055/html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/hmbci-2020-0055" target="_blank" >10.1515/hmbci-2020-0055</a>
Alternative languages
Result language
angličtina
Original language name
Vitamin D and new insights into pathophysiology of type 2 diabetes
Original language description
Deficiency in vitamin D plays a role in the onset and development of insulin resistance (IR) and type 2 diabetes (T2DM). A normal level of vitamin D is able to reduce low grade inflammation, which is a major process in inducing insulin resistance. It is also engaged in maintaining low resting levels of reactive species and radicals, normal Ca2+ signaling, a low expression of pro-inflammatory cytokines but increased formation of anti-inflammatory cytokines. Vitamin D is also able to prevent hypermethylation (of DNA) and consequent functional inactivation of many genes, as well as other epigenetic alterations in beta cells and in other insulin-sensitive peripheral tissues, mainly liver, adipose tissue and muscle. Vitamin D deficiency thus belongs to key factors accelerating the development of IR and consequently T2DM as well. However, vitamin D supplementation aimed at the control of glucose homeostasis in humans showed controversial effects. As a result, further studies are running to gain more detailed data needed for the full clinical utilization of vitamin D supplementation in the prevention and treatment of T2DM. Until new results are published, supplementation with high doses of vitamin D deficiency is not recommended. However, prevention of vitamin D deficiency and its correction are highly desired.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
ISSN
1868-1883
e-ISSN
1868-1891
Volume of the periodical
42
Issue of the periodical within the volume
2
Country of publishing house
DE - GERMANY
Number of pages
6
Pages from-to
203-208
UT code for WoS article
000680686500014
EID of the result in the Scopus database
2-s2.0-85102207478