Multiglandular Parathyroid Disease in Primary Hyperparathyroidism With Inconclusive Conventional Imaging

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023761%3A_____%2F22%3AN0000019" target="_blank" >RIV/00023761:_____/22:N0000019 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/22:10444248 RIV/00064203:_____/22:10444248 RIV/00216208:11110/22:10444248 RIV/00216208:11130/22:10444248
Result on the web
<a href="https://www.biomed.cas.cz/physiolres/pdf/2022/71_233.pdf" target="_blank" >https://www.biomed.cas.cz/physiolres/pdf/2022/71_233.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.934851" target="_blank" >10.33549/physiolres.934851</a>

Result language
angličtina
Original language name
Multiglandular Parathyroid Disease in Primary Hyperparathyroidism With Inconclusive Conventional Imaging
Original language description
Inconclusive preoperative imaging is a strong predictor of multiglandular parathyroid disease (MGD) in patients with primary hyperparathyroidism (PHPT). MGD was investigated in a cohort of 17 patients with PHPT (mean age 64.9 years, total calcium 2.75 mmol/1 and parathyroid hormone (PTH) 113.3 ng/l) who underwent F-18-fluorocholine PET/CT (FCH) imaging before surgery. The initial MIBI SPECT scintigraphy (MIBI) and/or neck ultrasound were not conclusive or did not localize all pathological parathyroid glands, and PHPT persisted after surgery. Sporadic MGD was present in 4 of 17 patients with PHPT (24 %). In 3 of 4 patients with MGD, FCH correctly localized 6 pathological parathyroid glands and surgery was successful. Excised parathyroid glands were smaller (p <0.02) and often hyperplastic in MGD than in single gland disease. In two individuals with MGD, excision of a hyperplastic parathyroid gland led to a false positive decline in intraoperative PTH and/or postoperative serum calcium. Although in one patient it was associated with partial false negativity, parathyroid imaging with FCH seemed to be superior to neck ultrasound and/or MIBI scintigraphy in MGD.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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