Iodine supply and thyroid function in women with gestational diabetes mellitus: a cohort study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023761%3A_____%2F24%3AN0000031" target="_blank" >RIV/00023761:_____/24:N0000031 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/24:10483705 RIV/00216208:11120/24:43927506 RIV/00064173:_____/24:43927506 RIV/00064165:_____/24:10483705

Result on the web

<a href="https://doi.org/10.1530/EC-24-0295" target="_blank" >https://doi.org/10.1530/EC-24-0295</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1530/EC-24-0295" target="_blank" >10.1530/EC-24-0295</a>

Result language

angličtina

Original language name

Iodine supply and thyroid function in women with gestational diabetes mellitus: a cohort study

Original language description

INTRODUCTION: Maternal urinary iodine concentration (UIC) and blood neonatal thyroid stimulating hormone (TSH) concentration reflect iodine status in pregnancy. As dietary measures in gestational diabetes mellitus (GDM) could affect iodine intake, our study aimed to investigate iodine supply in women with GDM compared to healthy pregnant women and to evaluate its relationship to thyroid function. METHODS: UIC and serum TSH, free thyroxine (FT4) and autoantibodies against thyroid peroxidase (TPOAb) were analysed in 195 women with GDM and 88 healthy pregnant women in the 2nd trimester. Subsequently, neonatal TSH concentrations measured 72 hours after delivery in a subgroup of 154 newborns (115 of mothers with GDM and 39 controls) from the national register were analysed. RESULTS: Optimal iodine intake was found only in nine women with GDM (4.6%) and 33 healthy pregnant women (37.5%) (P<0.001). Most pregnant women with GDM (88.7%) as compared to one half of controls (50%) had iodine deficiency (P<0.001). Also, hypothyroxinaemia was more prevalent in GDM compared to controls (12.3% vs 3.4%, P = 0.032). Consistently, neonatal TSH >5.0 mIU/L indicating iodine deficiency was found in 6 (5.2%) newborns of women with GDM as compared to none in controls. In the multiple logistic and linear regression models in women with GDM, hypothyroxinaemia was associated with preterm births, and a negative association of serum FT4 and HbA1c was found. CONCLUSION: Iodine deficiency in pregnancy was more prevalent among women with GDM compared to healthy pregnant controls. Hypothyroxinaemia was associated with preterm births in women with GDM.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Endocrine Connections

ISSN

2049-3614

e-ISSN

2049-3614

Volume of the periodical

13

Issue of the periodical within the volume

11

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

e240295

UT code for WoS article

001361648600010

EID of the result in the Scopus database

2-s2.0-85207502417